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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v32.i5.10
pages 373-462

The Inflammatory Process Underlying Atherosclerosis

M.Teresa Montero-Vega
Department of Research in Biochemistry, Ramon y Cajal Institute for Health Research (IRYCIS), Ramon y Cajal University Hospital, Ctra. Colmenar, km 9, 28034-Madrid, Spain

要約

Atherosclerosis is considered an inflammatory disease that starts and evolves in response to cholesterol accumulation in the arterial intima of the large and medium arteries. In recent years, new insights into innate immunity have changed our understanding of the events that initiate and drive inflammation, changing many concepts about pathogenesis of inflammatory disorders and on the susceptibility to infections. This review summarizes some of the current concepts on innate immunity and rearranges old and new data on pathogenesis in atherosclerosis to shed light on the disease with a new inflammatory view.


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