年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
Functions of Fascin in Dendritic Cells
要約
Fascin-1 is an actin-bundling protein that shares no homology with other actin-bundling proteins. It is greatly induced upon maturation of dendritic cells (DCs). However, fascin-1 is not expressed in other primary blood cells, including macrophages and neutrophils, indicating a unique role of fascin-1 in the function of DCs upon maturation. An increasing body of evidence has shown that fascin-1 plays critical roles in maturation-associated DC functions, including dynamic assembly of veil-like membrane protrusions, disassembly of podosomes, migration to lymph nodes, and the assembly of the immunological synapse. Pathological analyses of fascin-1 expression revealed that fascin-1 is a useful marker of diseases of immune cells, including Langerhans cell histiocytosis and Hodgkin diseases. Furthermore, attempts have been made to explore the use of a fascin-1 promoter for DNA vaccination because it is strong and specific to DCs.
-
Ma Yafeng, Machesky Laura M., Fascin1 in carcinomas: Its regulation and prognostic value, International Journal of Cancer, 137, 11, 2015. Crossref
-
Goitia Veronica, Oquendo Marcial, Stratton Robert, Case of 7p22.1 Microduplication Detected by Whole Genome Microarray (REVEAL) in Workup of Child Diagnosed with Autism, Case Reports in Genetics, 2015, 2015. Crossref
-
Ramos-Vara José A., Borst Luke B., Immunohistochemistry, in Tumors in Domestic Animals, 2016. Crossref
-
Le Texier Laëtitia, Durand Justine, Lavault Amélie, Hulin Philippe, Collin Olivier, Le Bras Yvan, Cuturi Maria-Cristina, Chiffoleau Elise, Appel Silke, LIMLE, a New Molecule Over-Expressed following Activation, Is Involved in the Stimulatory Properties of Dendritic Cells, PLoS ONE, 9, 4, 2014. Crossref
-
Rai Vikrant, Rao Velidi H., Shao Zhifei, Agrawal Devendra K., Chu Hong Wei, Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis, PLOS ONE, 11, 5, 2016. Crossref
-
Xu Xiaoli, Liu Xianmei, Long Jinhua, Hu Zuquan, Zheng Qinni, Zhang Chunlin, Li Long, Wang Yun, Jia Yi, Qiu Wei, Zhou Jing, Yao Weijuan, Zeng Zhu, Wu Yuntao, Interleukin-10 reorganizes the cytoskeleton of mature dendritic cells leading to their impaired biophysical properties and motilities, PLOS ONE, 12, 2, 2017. Crossref
-
Yamashiro Shigeko, Matsumura Fumio, Fascin, in Encyclopedia of Signaling Molecules, 2016. Crossref
-
Yamashiro Shigeko, Matsumura Fumio, Fascin, in Encyclopedia of Signaling Molecules, 2018. Crossref
-
Hobernik Dominika, Bros Matthias, DNA Vaccines—How Far From Clinical Use?, International Journal of Molecular Sciences, 19, 11, 2018. Crossref
-
Adzigbli Linda, Wang Ziman, Li Junhui, Deng Yuewen, Survival, retention rate and immunity of the black shell colored stocks of pearl oyster Pinctada fucata martensii after grafting operation, Fish & Shellfish Immunology, 98, 2020. Crossref
-
Ronchese Franca, Hilligan Kerry L, Mayer Johannes U, Dendritic cells and the skin environment, Current Opinion in Immunology, 64, 2020. Crossref
-
Sudowe Stephan, Höhn Yvonne, Renzing Andrea, Maxeiner Joachim, Montermann Evelyn, Habermeier Alice, Closs Ellen, Bros Matthias, Reske-Kunz Angelika B., Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells, Amino Acids, 52, 3, 2020. Crossref
-
Blumenthal Daniel, Chandra Vidhi, Avery Lyndsay, Burkhardt Janis K, Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex, eLife, 9, 2020. Crossref
-
Auray Gaël, Talker Stephanie C., Keller Irene, Python Sylvie, Gerber Markus, Liniger Matthias, Ganges Llilianne, Bruggmann Rémy, Ruggli Nicolas, Summerfield Artur, High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo, Frontiers in Immunology, 11, 2020. Crossref
-
Rodríguez-Fernández José Luis, Criado-García Olga, The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref
-
Matsumura Fumio, Polz Robin, Singh Sukhwinder, Matsumura Aya, Scheller Jürgen, Yamashiro Shigeko, Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis, The Journal of Immunology, 207, 3, 2021. Crossref
-
Kim Hye-Ran, Park Jeong-Su, Park Jin-Hwa, Yasmin Fatima, Kim Chang-Hyun, Oh Se Kyu, Chung Ik-Joo, Jun Chang-Duk, Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy, Journal of Hematology & Oncology, 14, 1, 2021. Crossref
-
Wang Yufeng, Song Mei, Liu Ming, Zhang Guoan, Zhang Xian, Li Ming O., Ma Xiaojing, Zhang J. Jillian, Huang Xin-Yun, Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity, Cell Reports, 35, 1, 2021. Crossref
-
Ku Min-Chi, Edes Inan, Bendix Ivo, Pohlmann Andreas, Waiczies Helmar, Prozorovski Tim, Günther Martin, Martin Conrad, Pagès Gilles, Wolf Susanne A., Kettenmann Helmut, Uckert Wolfgang, Niendorf Thoralf, Waiczies Sonia, ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas, Molecular Cancer Therapeutics, 15, 8, 2016. Crossref
-
Kirkling Margaret E., Cytlak Urszula, Lau Colleen M., Lewis Kanako L., Resteu Anastasia, Khodadadi-Jamayran Alireza, Siebel Christian W., Salmon Hélène, Merad Miriam, Tsirigos Aristotelis, Collin Matthew, Bigley Venetia, Reizis Boris, Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells, Cell Reports, 23, 12, 2018. Crossref
-
Alam Jehan, Yazdanpanah Ghasem, Ratnapriya Rinki, Borcherding Nicholas, de Paiva Cintia S., Li DeQuan, Pflugfelder Stephen C., Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes, Mucosal Immunology, 15, 4, 2022. Crossref
-
Mucke Hermann A.M., Drug Repurposing Patent Applications July–September 2022, ASSAY and Drug Development Technologies, 20, 8, 2022. Crossref