ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v17.i1.40
pages 89-118

Accessory Molecule and Costimulation Requirements for CD4 T Cell Response

Michael Croft
Department of Biology and the Cancer Center, University of California San Diego, La Jolla, CA 92093
Caroline Dubey
Department of Biology and the Cancer Center, University of California San Diego, La Jolla, CA 92093

要約

T cell activation is brought about by recognition of peptide/MHC complexes on an antigen-presenting cell (APC) by the T cell receptor (TCR). However, in general this appears to be insufficient for the full development of T cell responses and therefore additional signals are required, provided by ligation of counter-receptors on the T cell by APC accessory molecules. Although many studies have suggested that B7 molecules (CD80/CD86) binding to CD28 induce this second signal, it is now evident that any one of a number of molecules may provide accessory function and that efficient response is only generated following multiple interactions. It has also become clear that T cells exist in varying states of activation or differentiation, and that requirements for accessory molecules and costimuli are not always equivalent. This review covers much of the recent data regarding accessory molecule regulation of T cell responses. A modified version of the two signal model is presented, suggesting that the major function of accessory molecules during the initial stages of activation is to augment the ability to signal through the TCR, and that the primary role of costimulatory signals is to allow IL-2 secretion and growth. The requirement for multiple accessory molecule interactions is discussed in relation to activation of naive T cells and how such interactions are less critical at the memory and effector stages. Finally, this new information is related to how T cells interact with varying APC and how these interactions may modulate T cell response.


Articles with similar content:

Accessory Molecule and Costimulation Requirements for CD4 T Cell Response
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6
Caroline Dubey, Michael Croft
NK Cells and Their Ability to Modulate T Cells during Virus Infections
Critical Reviews™ in Immunology, Vol.34, 2014, issue 5
Kevin D. Cook, Stephen N. Waggoner, Jason K. Whitmire
Regulation of Th17 Maturation by Interleukin 4
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5
Laura A. Cooney , David A. Fox
Signal Integration Following Toll-like Receptor Triggering
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Alexander Dalpke, Klaus Heeg
How Can the Innate Immune System Influence Autoimmunity in Type 1 Diabetes and Other Autoimmune Disorders?
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
L. Wen, F. S. Wong