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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v20.i4.30
12 pages

CD5 Signal Transduction: Positive or Negative Modulation of Antigen Receptor Signaling

Francisco Lozano
Group of Immune Receptors of the Innate and Adaptive System, IDIBAPS; Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona; Servei d'Immunologia, Hospital Clinic de Barcelona, Barcelona, Spain
Maria Simarro
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Javier Calvo
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Josep M. Vila
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Olga Padilla
Servei d’Immunologia, Institut Clinic d’Infeccions i Immunologia (ICII), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain
Michael A. Bowen
Immunology and Inflammation Department, Bristol Myers-Squibb Pharmaceutical Research Institute, Princeton, New Jersey
Kerry S. Campbell
Fox Chase Cancer Center, Institute for Cancer Research, Division of Basic Science, Philadelphia, Pennsylvania

要約

The CD5 lymphocyte surface glycoprotein is a coreceptor involved in the modulation of antigen-specific receptor-mediated activation and differentiation signals. Although first considered a costimulatory molecule in mature peripheral T cells, recent studies of CD5−/− mice have opened the possibility that CD5 may also mediate inhibitory signals that attenuate TCR/CD3- and BCR-mediated triggering in thymocytes and a subgroup of B cells (B-1a cells), respectively. The ultimate molecular basis for these differential modulatory properties of CD5, depending on the context of lymphocyte subset and differentiation stage, are presently unknown and are an issue of current intensive investigation. Here, we review recent reports, both contradictory and complementary, focused on CD5-mediated molecular intracellular signaling events that could provide the basis for its immunomodulatory properties.


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