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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013007909
pages 477-488

Regulation of Antiviral CD8 T-Cell Responses

Joseph M. Kulinski
Microbiology and Medical Genetics Medical College of Wisconsin, Milwaukee, Wisconsin
Vera L. Tarakanova
Microbiology and Medical Genetics Medical College of Wisconsin; Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin
James Verbsky
Departments of Pediatrics, Medical College of Wisconsin; Microbiology and Medical Genetics Medical College of Wisconsin, Milwaukee, Wisconsin

要約

A balanced immune response to a viral pathogen leads to clearance of the virus while limiting immune mediated pathology. Control of this process occurs at all stages of the immune response, including during the induction of an antiviral response, clearance of virally infected cells, and the resolution of this response. Regulation of antiviral immune response is further modified when the immune system fails to clear the pathogen and by the nature of chronic infection itself. A number of processes have been implicated in the regulation of antiviral immune responses, such as the limitation of viral antigen load by interferons, apoptosis through cytokine withdrawal or Fas-mediated killing, and control of these responses by regulatory T cells. This review addresses several of these mechanisms.


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