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Critical Reviews™ in Therapeutic Drug Carrier Systems

年間 6 号発行

ISSN 印刷: 0743-4863

ISSN オンライン: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Formulation, Stability, and Delivery of Live Attenuated Vaccines for Human Use

巻 16, 発行 1, 1999, 83 pages
DOI: 10.1615/CritRevTherDrugCarrierSyst.v16.i1.10
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要約

The successful use of live attenuated viral and bacterial vaccines depends not only on the proper choice and delivery of the microorganisms, but also on maintaining the sufficient potency required for an immune response. The inherent lability of live organisms presents a particular formulation challenge in terms of stabilizing and preserving vaccine viability during manufacturing, storage, and administration. This review examines pharmaceutical approaches to the stabilization, formulation, and lyophilization of biological macromolecules in general, as well as the specific applicability of these principles to live attenuated viral and bacterial vaccines. Several formulation development case studies with live vaccines are presented. In addition, comparative stability data are summarized for many other live viral and bacterial preparations. Various pharmaceutical issues with conventional and novel delivery systems for administration of parenteral and oral live vaccines are also discussed.

によって引用された
  1. Bora Durlav Prasad, Bhanupraka Veerakyathappa, Venkatesan Gnanavel, Balamuruga Vinayagamurthy, Prabhu Manimuthu, Yogisharad Revanaiah, Effect of Stabilization and Reconstitution on the Stability of a Novel Strain of Live Attenuated Orf Vaccine (ORFV MUK59/05), Asian Journal of Animal and Veterinary Advances, 10, 8, 2015. Crossref

  2. Dumpa N., Goel K., Guo Yuhan, McFall H., Pillai Amit Raviraj, Shukla Ashay, Repka M. A., Murthy S. Narasimha, Stability of Vaccines, AAPS PharmSciTech, 20, 2, 2019. Crossref

  3. Xu Haiyue, Bhowmik Tuhin, Gong Kevin, Huynh Thu Ngoc Anh, Williams Robert O., Cui Zhengrong, Thin-film freeze-drying of a bivalent Norovirus vaccine while maintaining the potency of both antigens, International Journal of Pharmaceutics, 609, 2021. Crossref

  4. Parsa Saba, Pfeifer Blaine, Engineering Bacterial Vectors for Delivery of Genes and Proteins to Antigen-Presenting Cells, Molecular Pharmaceutics, 4, 1, 2007. Crossref

  5. Farooqui Misbah , Sultan Amir , Khan Hassan Ahmed , Thermostable Vaccines: Past, Present and Future Perspectives, Pakistan BioMedical Journal, 2, 1, 2019. Crossref

  6. Jain Annish, Singh Sumit K., Arya Shailendra K., Kundu Subhas C., Kapoor Sonia, Protein Nanoparticles: Promising Platforms for Drug Delivery Applications, ACS Biomaterials Science & Engineering, 4, 12, 2018. Crossref

  7. Nahak Bishal Kumar, Mishra Anshuman, Preetam Subham, Tiwari Ashutosh, Advances in Organ-on-a-Chip Materials and Devices, ACS Applied Bio Materials, 5, 8, 2022. Crossref

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