年間 6 号発行
ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X
Indexed in
Bioerodible Polymers for Ocular Drug Delivery
要約
Development of ophthalmic drug-delivery systems has always been challenging. The commonly used route for drug delivery to the anterior segment of the eye has been the conjunctival cul-de-sac. Because of drawbacks associated with this route, new approaches have been investigated for delivery of drugs to the eye by means of polymeric delivery systems. Development of controlled drug-release devices has been a major step forward in this respect. Bioerodible polymers have been at the forefront of such systems. They are very important because they eliminate the need for removing the implant after complete drug release. Bioerodible polymers have been divided into three classes based on their mechanism of hydrolysis: Type Ihydrolysis of crosslinked hydrogels; Type IIsolubilization by ionization or hydrolysis of linear polymers; and Type IIIbiodegradation by backbone cleavage. Polymers from all three classes are discussed in detail in this review.
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