ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Therapeutic Drug Carrier Systems
インパクトファクター: 2.9 5年インパクトファクター: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X

巻:
巻 38, 2021 巻 37, 2020 巻 36, 2019 巻 35, 2018 巻 34, 2017 巻 33, 2016 巻 32, 2015 巻 31, 2014 巻 30, 2013 巻 29, 2012 巻 28, 2011 巻 27, 2010 巻 26, 2009 巻 25, 2008 巻 24, 2007 巻 23, 2006 巻 22, 2005 巻 21, 2004 巻 20, 2003 巻 19, 2002 巻 18, 2001 巻 17, 2000 巻 16, 1999 巻 15, 1998 巻 14, 1997 巻 13, 1996 巻 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v33.i1.20
pages 1-39

Current Trends in Self-Emulsifying Drug Delivery Systems (SEDDSs) to Enhance the Bioavailability of Poorly Water-Soluble Drugs

Rohit Karwal
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
Tarun Garg
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
Goutam Rath
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Punjab Technical University, Kapurthala, Punjab, India
Tanmay S. Markandeywar
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India

要約

The main object of the self-emulsifying drug-delivery system (SEDDS) is oral bioavailability (BA) enhancement of a poorly water-soluble drug. Low aqueous solubility and low oral BA are major concerns for formulation scientists. As many drugs are lipophilic in nature, their lower solubility and dissolution are major drawbacks for their successful formulation into oral dosage forms. More than 60% of drugs have a lipophilic nature and exhibit poor aqueous solubility. Various strategies are reported in the literature to improve the solubility and enhance BA of lipophilic drugs, including the formation of a cyclodextrin complex, solid dispersions, and micronization. SEDDSs are ideally isotropic mixtures of drug, oil, surfactant, and/or cosurfactant. SEDDSs have gained increasing attention for enhancing oral BA and reducing drug dose. SEDDSs also provide an effective and excellent solution to the various issues related to the formulation of hydrophobic drugs that have limited solubility in gastrointestinal fluid. Our major focus of this review is to highlight the importance of SEDDSs in oral BA enhancement of poorly water-soluble drugs.


Articles with similar content:

Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.37, 2020, issue 4
Pradeep Mishra, Meenakshi Bajpai, Sonia Singh
Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin
Insights into the Approach, Fabrication, Application, and Lacunae of Nanoemulsions in Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.37, 2020, issue 6
Subhabrata Ray, Mahfoozur Rahman, Kumar Anand, Sanmoy Karmakar
Current Nanotechnological Strategies for Effective Delivery of Bioactive Drug Molecules in the Treatment of Tuberculosis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 1
Mandeep Kaur, Goutam Rath, Tarun Garg, Amit Kumar Goyal
Use of Nonionic Block Copolymers in Vaccines and Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.15, 1998, issue 2
Mark J. Newman, Jeffrey K. Actor, Mannersamy Balusubramanian, Chinnaswamy Jagannath