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Special Topics & Reviews in Porous Media: An International Journal
ESCI SJR: 0.277 SNIP: 0.52 CiteScore™: 1.3

ISSN 印刷: 2151-4798
ISSN オンライン: 2151-562X

Special Topics & Reviews in Porous Media: An International Journal

DOI: 10.1615/SpecialTopicsRevPorousMedia.v5.i4.70
pages 361-367

FEASIBILITY OF CLINOPTILOLITE APPLICATION AS A MICROPOROUS CARRIER FOR PH-CONTROLLED ORAL DELIVERY OF METRONIDAZOLE

Mahdi Tondar
Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA
Bahram Jambar Nooshin
Department of Medical Nanotechnology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Seyed Farid Shetab-Boushehri
Ameretat Shimi Pharmaceutical Company, Tehran, I.R. Iran
Seyed Vahid Shetab-Boushehri
Department of Medical Nanotechnology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran

要約

Clinoptilolite is a natural zeolite that found many applications in industries and medicine due to its high surface area/volume ratio. Metronidazole is an acidic drug that is currently used as an antimicrobial and antiparasitic drug, which induces gastric disturbances due to gastric mucosal irritation. In the present work, adsorption and desorption of metronidazole on Iranian clinoptilolite micronized particles were studied in acidic and relatively alkaline pH. The effect of the particle size of clinoptilolite was also investigated in relation to adsorption and desorption of metronidazole. The specific surfaces, particle sizes, and zeta potentials of clinoptilolite particles were also determined. Scanning electron microscopy was used to study the morphology and crystallinity of clinoptilolite particles. The results showed that adsorption and desorption of metronidazole on clinoptilolite are particle-size and pH dependent. The present work proposes clinoptilolite as an inexpensive, efficient, and non-toxic naturally available microporous material for metronidazole oral delivery.


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