ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN 印刷: 0893-9675
ISSN オンライン: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v13.i1.10
pages 1-38

Molecular Mechanisms of Apoptosis in Prostate Cancer

Petra I. Lorenzo
Department of Molecular Biosciences, University of Oslo, Postboks 1041, Blindern, 0316 Oslo, Norway
Yke J. Arnoldussen
Department of Molecular Biosciences, University of Oslo, Postboks 1041, Blindern, 0316 Oslo, Norway
Fahri Saatcioglu
Department of Molecular Biosciences, University of Oslo, Postboks 1041, Blindern, 0316 Oslo, Norway

要約

Prostate cancer is the most frequently diagnosed noncutaneous cancer in men in Western countries. As in the normal prostate, the initial stages of prostate cancer progression depend on androgens that increase proliferation and inhibit apoptosis. Androgen-deprivation therapy is the major course of treatment in recurrent and metastatic prostate cancer. However, in most cases prostate cancer progresses to an apoptosis-resistant androgen-independent stage for which there is no available therapy. It is therefore important to understand the molecular mechanisms underlying prostate cancer progression, and how prostate cancer cells evade apoptotic mechanisms that give rise to their uncontrolled growth behavior. Here, we have reviewed the most important signaling pathways implicated in prostate cancer apoptosis and cell growth and how they may be deregulated during prostate cancer progression.


Articles with similar content:

Toward an Understanding of the Molecular Genetics of Prostate Cancer Progression
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 1
Marijana Lijovic, Albert G. Frauman
Possible Role of Epidermal Growth Factor Receptors in the Therapy of Pancreatic Cancer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
R. S. R. Murthy, Suresh P. Vyas, Manish K. Gupta, Sahil Aggarwal, Swati Gupta
miRNA: A Diagnostic and Therapeutic Tool for Pancreatic Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Muhammad Imran Qadir, Arooj Faheem
Natural Products as Inhibitors of Epidermal Growth Factor Receptor
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 4
Thomas Efferth
The Immune System in the Pathogenesis of Ovarian Cancer
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Ellen L. Goode, Kimberly R. Kalli, Keith L. Knutson, Melissa S. DeRycke, Bridget Charbonneau