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Critical Reviews™ in Oncogenesis

年間 4 号発行

ISSN 印刷: 0893-9675

ISSN オンライン: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Tracking Down the Origin of Cancer: Metabolic Reprogramming as a Driver of Stemness and Tumorigenesis

巻 19, 発行 5, 2014, pp. 363-382
DOI: 10.1615/CritRevOncog.2014011844
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要約

Metabolic reprogramming has recently emerged as a fundamental trait of cancer cells. Initially thought to be a consequence of rapid cell proliferation, recent data have reset this idea by demonstrating that metabolic reprogramming can actually drive tumorigenesis. The cancer stem cell (CSC) theory predicts that only a small subpopulation of cancer cells with stem cell properties, which derive from the cancer cell of origin, possesses tumor-initiating potential. However, whether metabolic reprogramming drives tumor formation by regulating the genesis of CSCs is not known. Importantly, the metabolic properties of stem cells and cancer cells are strikingly similar, and metabolic reprogramming is a key factor controlling stemness in these cells. This article reviews the current understanding of cancer metabolism and how it mirrors the metabolic requirements of stem cells. These two concepts are integrated and data demonstrating that metabolic reprogramming regulates CSCs function are discussed, suggesting that metabolic regulation of stemness could be at the origin of cancer.

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  1. Wang Yi, He Du, Yang Liang, Wen Bo, Dai Jinfen, Zhang Qian, Kang Jian, He Weiyang, Ding Qianshan, He De, TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis, Biochemical and Biophysical Research Communications, 463, 3, 2015. Crossref

  2. Gambichler Thilo, Kohsik Christina, Höh Ann-Kathrin, Lang Kerstin, Käfferlein Heiko U., Brüning Thomas, Stockfleth Eggert, Stücker Markus, Dreißigacker Max, Sand Michael, Expression of PIWIL3 in primary and metastatic melanoma, Journal of Cancer Research and Clinical Oncology, 143, 3, 2017. Crossref

  3. Becker Sarah F, Jarriault Sophie, Natural and induced direct reprogramming: mechanisms, concepts and general principles — from the worm to vertebrates, Current Opinion in Genetics & Development, 40, 2016. Crossref

  4. Li Jingjing, Dai Weiqi, Xia Yujing, Chen Kan, Li Sainan, Liu Tong, Zhang Rong, Wang Jianrong, Lu Wenxia, Zhou Yuqing, Yin Qin, Abudumijiti Huerxidan, Chen Rongxia, Zheng Yuanyuan, Wang Fan, Lu Jie, Zhou Yingqun, Guo Chuanyong, Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro, Marine Drugs, 13, 10, 2015. Crossref

  5. Petanidis Savvas, Kioseoglou Efrosini, Domvri Kalliopi, Zarogoulidis Paul, Carthy Jon M., Anestakis Doxakis, Moustakas Aristidis, Salifoglou Athanasios, In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients, The International Journal of Biochemistry & Cell Biology, 74, 2016. Crossref

  6. Naik Prajna Paramita, Das Durgesh Nandini, Panda Prashanta Kumar, Mukhopadhyay Subhadip, Sinha Niharika, Praharaj Prakash Priyadarshi, Agarwal Rajesh, Bhutia Sujit Kumar, Implications of cancer stem cells in developing therapeutic resistance in oral cancer, Oral Oncology, 62, 2016. Crossref

  7. Cecchetti Serena, Bortolomai Ileana, Ferri Renata, Mercurio Laura, Canevari Silvana, Podo Franca, Miotti Silvia, Iorio Egidio, Papaccio Gianpaolo, Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma, PLOS ONE, 10, 9, 2015. Crossref

  8. Kohno Susumu, Kitajima Shunsuke, Sasaki Nobunari, Takahashi Chiaki, Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies, World Journal of Stem Cells, 8, 4, 2016. Crossref

  9. Kalacheva Nadezhda V., Eliseikina Marina G., Frolova Lidia T., Dolmatov Igor Yu., Schubert Michael, Regeneration of the digestive system in the crinoid Himerometra robustipinna occurs by transdifferentiation of neurosecretory-like cells, PLOS ONE, 12, 7, 2017. Crossref

  10. Vermeersch Kathleen A., Wang Lijuan, Mezencev Roman, McDonald John F., Styczynski Mark P., Singh Pankaj K, OVCAR-3 Spheroid-Derived Cells Display Distinct Metabolic Profiles, PLOS ONE, 10, 2, 2015. Crossref

  11. Qian Xuchen, Yang Zhitao, Mao Enqiang, Chen Erzhen, Regulation of fatty acid synthesis in immune cells, Scandinavian Journal of Immunology, 88, 5, 2018. Crossref

  12. Shimamura Mika, Yamamoto Kazuo, Kurashige Tomomi, Nagayama Yuji, Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines, Experimental Cell Research, 370, 2, 2018. Crossref

  13. Vartanian A. A., Oborotova M. V., BASIC DETERMINANTS OF MELANOMA STEM CELL, Russian Journal of Biotherapy, 14, 2, 2015. Crossref

  14. Yang Fan, Shu Le, Zhang Xiaobo, Tumorigenesis and Metabolism Disorder, in Virus Infection and Tumorigenesis, 2019. Crossref

  15. Zhang Li, Yang Yongfeng, Chai Li, Bu Hong, Yang Ying, Huang Hong, Ran Jingjing, Zhu Yihan, Li Li, Chen Fei, Li Weimin, FRK plays an oncogenic role in non‐small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming , International Journal of Cancer, 146, 1, 2020. Crossref

  16. Li Na, Zhan Xiaohan, Zhan Xianquan, Energy Metabolism Heterogeneity-Based Molecular Biomarkers for Ovarian Cancer, in Molecular Medicine, 2019. Crossref

  17. Assumpção Carolina Baraúna, Calcagno Danielle Queiroz, Araújo Taíssa Maíra Thomaz, Batista dos Santos Sidney Emmanuel, Ribeiro dos Santos Ândrea Kely Campos, Riggins Gregory Joseph, Burbano Rommel Rodriguez, Assumpção Paulo Pimentel, The role of piRNA and its potential clinical implications in cancer, Epigenomics, 7, 6, 2015. Crossref

  18. Yang Fei-ran, Zhao Yu-feng, Hu Xi-wen, Liu Zong-kai, Yu Xiao-dan, Li Chang-yang, Li Xiu-rong, Li Hui-jie, Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming, Gene, 788, 2021. Crossref

  19. Li Yan, Lin Shuhai, Li Lei, Tang Zhi, Hu Yumin, Ban Xiaojiao, Zeng Tingting, Zhou Ying, Zhu Yinghui, Gao Song, Deng Wen, Zhang Xiaoshi, Xie Dan, Yuan Yunfei, Huang Peng, Li Jinjun, Cai Zongwei, Guan Xin-Yuan, PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism, Cancer Research, 78, 16, 2018. Crossref

  20. Hou Jue, Williams Joshua, Botvinick Elliot L., Potma Eric O., Tromberg Bruce J., Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State, Cancer Research, 78, 10, 2018. Crossref

  21. La Vecchia Sofia, Sebastián Carlos, Metabolic pathways regulating colorectal cancer initiation and progression, Seminars in Cell & Developmental Biology, 98, 2020. Crossref

  22. Guan Huifang, Xu Yan, Ma Chunyu, Zhao Dexi, Ramachandran Saravanan, Pharmacology, Toxicology, and Rational Application of Cinnabar, Realgar, and Their Formulations, Evidence-Based Complementary and Alternative Medicine, 2022, 2022. Crossref

  23. Wen Gui-Min, Xu Xiao-Yan, Xia Pu, Metabolism in Cancer Stem Cells: Targets for Clinical Treatment, Cells, 11, 23, 2022. Crossref

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