ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN 印刷: 0893-9675
ISSN オンライン: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v5.i4.10
pages 331-357

SV40-lnduced Immortalization of Human Cells

Tracy Bryan
Children's Medical Research Institute
Roger R. Redder
Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia

要約

For several decades simian virus 40 (SV40) early region genes have been used as a means of generating immortalized human cell lines; however, the molecular mechanisms of this process have begun to be understood only recently. SV40-induced immortalization proceeds via two phases. In the first phase ("lifespan extension"), cells continue proliferating for a limited number of population doublings beyond the point at which normal cells undergo senescence. This is mainly due to the ability of SV40 large T antigen (LTAg) to bind to the protein products of the p53 and retinoblastoma (Rb) genes. The second phase ("immortalization") occurs in only a small minority of cells, and cell hybridization analyses indicate that this is a gene inactivation event. The gene or genes involved are currently unknown, but chromosomal localization data are accumulating which should make their cloning and characterization possible in the near future.


Articles with similar content:

Immortalization of Human Cells and Its Mechanisms
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Koichiro Mihara, Kazuo Fushimi, Masayoshi Namba
Epithelial Mesenchymal Transition and Vascular Mimicry in Breast Cancer Stem Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 3
Srishti Kotiyal, Susinjan Bhattacharya
Cyclins, Cyclin-Dependent Kinases and Cdk Inhibitors: Implications in Cell Cycle Control and Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 2
Antonio Giordano, Timothy K. MacLachlan, Nianli Sang
Human Prostate Carcinogenesis
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 4
Hsiang-fu Kung, Johng S. Rhim
The Oncogenic Role of Human Papillomavirus Proteins
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Miguel S. Barbosa