ライブラリ登録: Guest
Critical Reviews™ in Oncogenesis

年間 4 号発行

ISSN 印刷: 0893-9675

ISSN オンライン: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Molecular Mechanisms Underlying the Role of MicroRNAs in Resistance to Epidermal Growth Factor Receptor-Targeted Agents and Novel Therapeutic Strategies for Treatment of Non-Small-Cell Lung Cancer

巻 18, 発行 4, 2013, pp. 317-326
DOI: 10.1615/CritRevOncog.2013007191
Get accessGet access

要約

Non–small cell lung cancer (NSCLC) is one of the deadliest types of cancer. One explanation for this poor prognosis is the failure of most chemotherapeutic regimens, which prompted the development of new, rationally designed, targeted antitumor agents, such as inhibitors of the epidermal growth factor receptor (EGFR) and downstream pathways. However, most of these targeted therapies also fail, and studies on the mechanisms underlying resistance toward targeted agents might provide critical findings for NSCLC research and treatment. Some of these studies showed that drug resistance can emerge not only from genetic aberrations, but also from epigenetic changes, including regulation of different signaling pathways by microRNAs (miRNAs), which act as key post-transcriptional regulators of gene expression. There is accumulating evidence that specific miRNAs correlated with drug sensitivity and can be used as prognostic markers in NSCLC. However, a greater knowledge of miRNAs might also provide novel insights in several drug-resistance mechanisms; hence, suggesting their potential in novel therapeutic interventions, by sensitizing tumor cells to drug-induced apoptosis as well as by inhibiting tumor proliferation and invasive capabilities. Therefore, this review highlights several recent and clinically relevant aspects of the regulation of drug resistance by miRNAs from the perspective of current anti-EGFR–targeted therapies in NSCLC.

によって引用された
  1. Bi Yueyang, Han Yong, Bi Haiyang, Gao Fuquan, Wang Xiaozhi, miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin, Human Cell, 27, 3, 2014. Crossref

  2. Qin Hai-Feng, Qu Li-Li, Liu Hui, Wang Sha-Sha, Gao Hong-Jun, Serum CEA Level Change and Its Significance Before and after Gefitinib Therapy on Patients with Advanced Non-small Cell Lung Cancer, Asian Pacific Journal of Cancer Prevention, 14, 7, 2013. Crossref

  3. Mirzaei Hamed, Gholamin Sharareh, Shahidsales Soodabeh, Sahebkar Amirhossein, Jaafari Mahmoud Reza, Mirzaei Hamid Reza, Hassanian Seyed Mahdi, Avan Amir, MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma, European Journal of Cancer, 53, 2016. Crossref

  4. GE XIAOJUN, ZHENG LIMEI, HUANG MIN, WANG YONGLUN, BI FENG, MicroRNA expression profiles associated with acquired gefitinib-resistance in human lung adenocarcinoma cells, Molecular Medicine Reports, 11, 1, 2015. Crossref

  5. Zhou Haiyu, Huang Zhizhou, Chen Xuemei, Chen Size, miR-98 inhibits expression of TWIST to prevent progression of non-small cell lung cancers, Biomedicine & Pharmacotherapy, 89, 2017. Crossref

  6. Ahmad Aamir, Ginnebaugh Kevin R., Li Yiwei, Bao Bin, Gadgeel Shirish M., Sarkar Fazlul H., miRNA Targeted Therapy in Lung Cancer, in MicroRNA Targeted Cancer Therapy, 2014. Crossref

  7. Gong Zhaohui, Dong Zhuo, Yang Lihua, Yang Jie, Li Jingqiu, Le Yanping, Wang Shaomin, Ye Meng, Lin Hui-Kuan, The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy, in MicroRNA Targeted Cancer Therapy, 2014. Crossref

  8. Wang Wen , Yang Jinsong , Yu Fenglei , Li Wenjie , Wang Li , Zou Haoyu , Long Xia , MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells, Oncology Letters, 2017. Crossref

  9. Shi Jingsheng, Wei Yibing, Xia Jun, Wang Siqun, Wu Jianguo, Chen Feiyan, Huang Gangyong, Chen Jie, CXCL12–CXCR4 contributes to the implication of bone marrow in cancer metastasis, Future Oncology, 10, 5, 2014. Crossref

Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain