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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN 印刷: 0893-9675
ISSN オンライン: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v9.i1.40
pages 43-62

The c-Fes Family of Protein-Tyrosine Kinases

Thomas E. Smithgall
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Jim A. Rogers
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Kristi L. Peters
Department of Molecular Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195-5285
Jianze Li
Department of Pathology, Columbia University, 630 W. 168th Street, New York, NY 10032
Scott D. Briggs
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Jack M. Lionberger
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Haiyun Cheng
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Annemarie Shibata
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Beata Scholtz
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Steven Schreiner
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805
Nancy Dunham
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-6805

要約

The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was later found to exhibit strong expression in myeloid hematopoietic cells and to play a direct role in their differentiation. Recent work has shown that Fes exhibits a more widespread expression pattern in both developing and adult tissues, suggesting a general physiological function for this kinase and its closely related homolog, Fer. This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families.


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