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Journal of Porous Media
インパクトファクター: 1.49 5年インパクトファクター: 1.159 SJR: 0.504 SNIP: 0.671 CiteScore™: 1.58

ISSN 印刷: 1091-028X
ISSN オンライン: 1934-0508

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Journal of Porous Media

DOI: 10.1615/JPorMedia.v12.i3.10
pages 201-212

Molecular Transport through Arterial Wall Composed of Smooth Muscle Cells and a Homogeneous Fiber Matrix

Mahsa Dabagh
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Payman Jalali
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Pertti Sarkomaa
Department of Energy and Environmental Technology, Lappeenranta University of Technology, 53851, Lappeenranta, Finland
Yrjo T. Konttinen
Department of Orthopaedics, Teaching Hospital, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Department of Orthopaedics, ORTON Orthopaedic Hospital, 00280 Helsinki, Finland; COXA Hospital for Joint Replacement, 33520 Tampere, Finland

要約

The molecular transport through an arterial wall is significantly influenced by the shape, distribution, and volume fraction of smooth muscle cells (SMCs). In the present study, a two-dimensional numerical simulation is performed to investigate the influence of the configuration of SMCs on the diffusion of Adenosine 5'-triphosphate (ATP) through the media layer of the arterial wall. The media layer is modeled as a heterogeneous porous medium composed of smooth muscle cells embedded in a continuous porous medium representing the interstitial proteoglycan and collagen fiber matrix. SMCs are distributed within the media layer in either ordered or disordered fashions at different volume fractions. The interstitial fluid enters the media through fenestral pores which are distributed uniformly over the internal elastic lamina (IEL). The probability density function (PDF) of the concentration of ATP is analyzed within the bulk in the presence of elliptic SMCs, which shows it to be lower than that in the presence of circular cells with the SMC volume fraction of 0.4. Moreover, the distribution of SMCs considerably affects the PDF of ATP within the bulk with the volume fraction of 0.7. Results indicate the importance of SMCs in the transport of molecules such as ATP within the arterial wall.


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