年間 6 号発行
ISSN 印刷: 0278-940X
ISSN オンライン: 1943-619X
Indexed in
Hybrid Superporous Scaffolds: An Application for Cornea Tissue Engineering
要約
Engineering a cell-based keratoprosthesis often requires a struggle between two essential parameters: natural 3-D biological adhesion and mechanical strength. A novel hybrid scaffold of natural and synthetic materials was engineered to achieve both cell adhesion and implantable strength. This scaffold was characterized in terms of cell adhesion, cell migration, swelling, and strength. While the study was focused on engineering a biointegrable prosthetic skirt, a clear central core with an appropriate refractive index and light transmission was also incorporated into the design for potential functionality. The hybrid scaffold was tested in rat corneas. This uniquely designed scaffold was well tolerated and encouraged host cell migration into the implant. The hybrid superporous design also enhanced cell adhesion and retention in a superporous scaffold without altering the bulk mechanical properties of the hydrogel.
-
Zellander Amelia, Gemeinhart Richard, Djalilian Ali, Makhsous Mohsen, Sun Shan, Cho Michael, Designing a gas foamed scaffold for keratoprosthesis, Materials Science and Engineering: C, 33, 6, 2013. Crossref
-
Farkas Balázs, Dante Silvia, Brandi Fernando, Photoinitiator-free 3D scaffolds fabricated by excimer laser photocuring, Nanotechnology, 28, 3, 2017. Crossref
-
Ma Xiao Yun, Zhang Yun, Zhu Dan, Lu Yang, Zhou Guangdong, Liu Wei, Cao Yilin, Zhang Wen Jie, Ljubimov Alexander V., Corneal Stroma Regeneration with Acellular Corneal Stroma Sheets and Keratocytes in a Rabbit Model, PLOS ONE, 10, 7, 2015. Crossref
-
Sinha Mukty, Gupte Tanvi, Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite, International Ophthalmology, 38, 3, 2018. Crossref
-
McAvoy Kathryn, Jones David, Thakur Raghu Raj Singh, Synthesis and Characterisation of Photocrosslinked poly(ethylene glycol) diacrylate Implants for Sustained Ocular Drug Delivery, Pharmaceutical Research, 35, 2, 2018. Crossref
-
Kim Jeong In, Kim Ju Yeon, Park Chan Hee, Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method, Scientific Reports, 8, 1, 2018. Crossref
-
Lee Yu-Ping, Liu Hsin-Yu, Lin Po-Chun, Lee Yi-Huan, Yu Leng-Rong, Hsieh Chih-Chen, Shih Po-Jen, Shih Wen-Pin, Wang I-Jong, Yen Jia-Yush, Dai Chi-An, Facile fabrication of superporous and biocompatible hydrogel scaffolds for artificial corneal periphery, Colloids and Surfaces B: Biointerfaces, 175, 2019. Crossref
-
Bhasin Arpita, Djalilian Ali, Movahedan Asadolah, Integrating Keratoprosthesis, in Keratoprostheses and Artificial Corneas, 2015. Crossref
-
Aghamollaei Hossein, Pirhadi Shiva, Shafiee Soodabeh, Sehri Mohammad, Goodarzi Vahabodin, Jadidi Khosrow, Application of polymethylmethacrylate, acrylic, and silicone in ophthalmology, in Materials for Biomedical Engineering, 2019. Crossref
-
Wang Jieqiong, Chen Yun, Bai Ying, Quan Daping, Wang Zhichong, Xiong Liming, Shao Zengwu, Sun Wei, Mi Shengli, A core-skirt designed artificial cornea with orthogonal microfiber grid scaffold, Experimental Eye Research, 195, 2020. Crossref
-
Mahdavi S. Sharareh, Abdekhodaie Mohammad J., Mashayekhan Shohreh, Baradaran-Rafii Alireza, Djalilian Ali R., Bioengineering Approaches for Corneal Regenerative Medicine, Tissue Engineering and Regenerative Medicine, 17, 5, 2020. Crossref
-
Lin Yu-Hsiang, Jian Jia-Hong, Li Jia-Han, Refractive Index Measurement of Corneal-Shaped Hydrogel Material and Elasmobranch Corneas by Shack–Hartmann Wavefront Sensor System, IEEE Transactions on Instrumentation and Measurement, 70, 2021. Crossref
-
Köllmer Melanie, Keskar Vandana, Hauk Thomas G., Collins John M., Russell Brenda, Gemeinhart Richard A., Stem Cell-Derived Extracellular Matrix Enables Survival and Multilineage Differentiation within Superporous Hydrogels, Biomacromolecules, 13, 4, 2012. Crossref
-
Ma Yu-Chi, Hsieh Chang-Tsung, Lin Yu-Hsiang, Dai Chi-An, Li Jia-Han, Numerical Study of Customized Artificial Cornea Shape by Hydrogel Biomaterials on Imaging and Wavefront Aberration, Polymers, 13, 24, 2021. Crossref
-
Palamaro Loredana, Guarino Vincenzo, Scalia Giulia, Antonini Dario, De Falco Luigia, Bianchino Gabriella, Fusco Anna, Romano Rosa, Grieco Vitina, Missero Caterina, Del Vecchio Luigi, Ambrosio Luigi, Pignata Claudio, Human skin-derived keratinocytes and fibroblasts co-cultured on 3D poly ε-caprolactone scaffold support in vitro HSC differentiation into T-lineage committed cells, International Immunology, 25, 12, 2013. Crossref