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Plasma Medicine

年間 4 号発行

ISSN 印刷: 1947-5764

ISSN オンライン: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Plasma-based Stimulation of Biotechnological Processes in Ganoderma lucidum Mycelia as Example for a Eukaryotic Organism

巻 4, 発行 1-4, 2014, pp. 17-28
DOI: 10.1615/PlasmaMed.2014011874
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要約

In biotechnological processes, high-yielding production strains are the condition for economic production of biomass and desired metabolites. Plasma with its components like UV radiation and highly reactive radicals could possibly generate and improve new production strains. Indeed, plasma was able to generate high-yielding bacterial strains. A candidate for eukaryotic cells for improving metabolite production is the medicinal mushroom Ganoderma lucidum used for prevention and treatment of many different diseases. Mycelia and fruit bodies contain more than 150 structurally different triterpens. The aim of our investigation was to check whether plasma influences growth and productivity of the fungus. Mycelial cultures were exposed to plasma for 2−20 min by using three different plasma sources: the plasma jet klNPen 09 and two dielectric barrier discharge plasma sources (surface-DBD, volume-DBD). Yield of biomass and extracts were determined. HPLC fingerprints of organic extracts were recorded. Content of triterpens, ganoderic acid A, ergosterol, and β-1-3 D-glucan was determined. Volume-DBD increased extract yield and β-1-3 D-glucan content, while whole triterpenoid content was increased by the plasma jet. Both dielectric barrier discharge plasma sources led to elevated ergosterol contents. The effects seemed to be related to energy input by the plasma sources. In conclusion, plasma could be principally useful for optimization of biotechnological processes not for only prokaryotic but also eukaryotic cells.

によって引用された
  1. Kramer Axel, Bekeschus Sander, Matthes Rutger, Bender Claudia, Stope Matthias B., Napp Matthias, Lademann Olaf, Lademann Jürgen, Weltmann Klaus-Dieter, Schauer Frieder, Cold Physical Plasmas in the Field of Hygiene-Relevance, Significance, and Future Applications, Plasma Processes and Polymers, 12, 12, 2015. Crossref

  2. Kramer Axel, Matthes Rutger, Bekeschus Sander, Bender Claudia, Napp Matthias, Lademann Olaf, Lademann Jürgen, Weltmann Klaus Dieter, Aktueller und perspektivischer Einsatz kalter Plasmen aus hygienischer Indikation, in Plasmamedizin, 2016. Crossref

  3. Shimizu Kazuo, Krištof Jaroslav, Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method, in Advanced Technology for Delivering Therapeutics, 2017. Crossref

  4. Reuter Stephan, von Woedtke Thomas, Weltmann Klaus-Dieter, The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications, Journal of Physics D: Applied Physics, 51, 23, 2018. Crossref

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