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Atomization and Sprays
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ISSN 印刷: 1044-5110
ISSN オンライン: 1936-2684

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Atomization and Sprays

DOI: 10.1615/AtomizSpr.v7.i4.60
pages 417-436

THEORETICAL INVESTIGATION OF THE SPRAY FROM A PRESSURIZED METERED-DOSE INHALER

C. A. Dunbar
Thermo-Fluids Division, Department of Mechanical Engineering, UMIST, Manchester, U.K.
J. F. Miller
Inhalation Product Development, GlaxoWellcome R&D, Hertfordshire, U.K.

要約

This research was concerned with the theoretical investigation of the spray issued from a pressurized metered-dose inhaler (pMDI). The theoretical investigation of the pMDI spray consisted of constructing a model of the fluid flow through the pMDI that was based on a quasi-steady-state separated flow analysis during a single actuation and included a qualitative and quantitative description of the primary atomization process, the resultant spray model being calculated from the solution of the multiphase transport equations using the discrete droplet model (DDM). The predicted results were validated against detailed temporal and spatial experimental data obtained using phase Doppler particle analysis (PDPA).


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