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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

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Association between 12p13 Polymorphisms and Ischemic Stroke in Asian Populations: New Evidence from a Case-Control Study and a Meta-Analysis

巻 29, 発行 4, 2019, pp. 363-375
DOI: 10.1615/CritRevEukaryotGeneExpr.2019028944
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要約

A genome-wide association study first reported the association between ischemic stroke risk and two polymorphisms on chromosome 12p13: rs12425791 and rs11833579. Since then, a series of studies have investigated the association of these two polymorphisms with stroke risk, but the results were inconsistent even in Asian populations. Thus, we carried out a case-control study to uncover the potential relationship, and then conducted a meta-analysis to further address the issue. 540 ischemic stroke patients and 540 unrelated controls were enrolled in the case-control study. Genotyping was accomplished by polymerase chain reaction-ligation detection reaction. The meta-analysis was conducted by combining our study with previous published data. In our case-control study, the significant association was observed between ischemic stroke and rs12425791 (AG vs. GG: OR = 1.32, P < 0.05) but not rs11833579. When pooled with previous studies, the significant relationship of rs12425791 with ischemic stroke was found (A vs. G: OR = 1.07, P < 0.05; AA + AG vs. GG: OR = 1.10, P < 0.05) in Asian populations, as well as in subgroup analysis. A correlation approaching significance was identified between ischemic stroke risk and rs11833579 (AA + AG vs. GG: OR = 1.06, P = 0.05). New evidence from this case-control study and meta-analysis indicates that 12p13 rs12425791/rs11833579 polymorphisms are associated with ischemic stroke susceptibility in Asian populations.

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によって引用された
  1. Bonnechère Bruno, Liu Jun, Thomson Alexander, Amin Najaf, van Duijn Cornelia, Does Ethnicity Influence Dementia, Stroke and Mortality Risk? Evidence from the UK Biobank, SSRN Electronic Journal , 2021. Crossref

  2. Jin Ming, Wang Ningning, Li Xueyan, Zhang Hao, Zhou Jexin, Cong Mingyu, Niu Jun, Lin Chongyang, Hu Ying, Wu Nan, Liu Jicheng, Zhang Keyong, Qiu Changchun, Relationship between MTHFR C677T, homocysteine, and ischemic stroke in a large sample of the Han Chinese population, Medicine, 101, 38, 2022. Crossref

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