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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Molecular Mechanisms and Therapeutic Potential of miR-493 in Cancer

巻 29, 発行 6, 2019, pp. 521-528
DOI: 10.1615/CritRevEukaryotGeneExpr.2019030056
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要約

MicroRNAs (miRNAs) are highly conserved short noncoding RNAs with the capacity of regulating gene expression posttranscriptionally. In this process, miRNAs partially bind complementary sites of target mRNAs. Among miRNAs, miR-493 performs important functions under diverse physiological conditions and participates in different pathogeneses, including pancreatic cancer, gastric cancer, and breast cancer. Differential expression of miR-493 plays a vital role in the generation, metastasis, and recurrence of tumors. Above all, increasing evidence indicates that miR-493 inhibits the generation and development of tumors by activating the Wnt/Β-catenin, Wnt/PCP, MEK/ERK, or PI3K/AKT signaling pathway, suggesting possibilities for miR-493 as an effective adjuvant cancer therapy. In this review, we discuss and summarize the biological mechanisms of miR-493 and its potential in cancer therapy. This review may provide a better understanding of the biological functions of miR-493 in tumors and provide important clues to cancer treatment.

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によって引用された
  1. Zhou Wa, Chen Yan-Xia, Ke Ben, He Jia-Ke, Zhu Na, Zhang A-Fei, Fang Xiang-Dong, Tu Wei-Ping, circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4, Epigenomics, 14, 4, 2022. Crossref

  2. Mustafin R. N., Molecular genetics of idiopathic pulmonary fibrosis, Vavilov Journal of Genetics and Breeding, 26, 3, 2022. Crossref

  3. Su Jinfang, Huang Yongbiao, Wang Yali, Li Rui, Deng Wanjun, Zhang Hao, Xiong Huihua, CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma, Cancer Cell International, 22, 1, 2022. Crossref

  4. Tang Binbin, Yuan Yifeng, Wang Shen, Li Shaohua, Kang Shifa, He Caijian, Zhou Hang, Fang Mouhao, Chen Tianpeng, Liu Kang, Shi Xiaolin, The Chinese herbal formula QiangGuYin regulates the Wnt/β-catenin pathway in osteoblasts by intervening in the expression of miRNAs derived from osteoclast exosomes, Pharmacological Research - Modern Chinese Medicine, 3, 2022. Crossref

  5. Mustafin R. N., Prospects for Treatment of Idiopathic Pulmonary Fibrosis, The Russian Archives of Internal Medicine, 12, 4, 2022. Crossref

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