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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Therapeutic Angiogenesis: A Case for Targeted, Regulated Gene Delivery

巻 10, 発行 2, 2000, 14 pages
DOI: 10.1615/CritRevEukarGeneExpr.v10.i2.10
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要約

Blood and vascular disorders underlie a plethora of pathological conditions and are the single most frequent cause of human disease. Eliminated or restricted blood flow to tissues as a result of vessel dysfunction results in the disruption of oxygen and nutrient delivery and the accumulation of waste metabolites. Cells cannot survive extended severe ischemia but may be able to adapt to a moderate condition where diffusion to and from bordering nonischemic regions sustain vital functions. Under this condition, secondary functions of affected cells are likely to be impaired and a new metabolic equilibrium is established, determined by the level of cross-diffusion. In tissues with a normally high metabolic turnover such as skeletal and cardiac muscle, ischemia causes hypoxia, acidosis, and depressed function (contractility). The treatment possibilities for tissue ischemia resulting from vascular disease are limited. Lipid-lowering agents may help slow the progression of vessel disease in some instances, but surgical reconstruction may be the only option in advanced stages, and even this is not always an option. An alternative and rather obvious strategy to treat ischemia is to activate endogenous angiogenic or vasculogenic pathways and stimulate revascularization of the tissue. The feasibility of such a strategy has now been established through the results of studies over the past decade and a new discipline called therapeutic angiogenesis has emerged. This review focuses on the application of therapeutic angiogenesis for treating peripheral limb ischemia and coronary artery diseases; the author traces the evidence supporting the feasibility of this treatment strategy, its current limitations, and possible directions.

によって引用された
  1. Kleinman H. K., Liau G., Gene Therapy for Antiangiogenesis, JNCI Journal of the National Cancer Institute, 93, 13, 2001. Crossref

  2. Zhao Hailin, Iwasaki Masae, Yang Jiali, Savage Sinead, Ma Daqing, Hypoxia-inducible factor-1: A possible link between inhalational anesthetics and tumor progression?, Acta Anaesthesiologica Taiwanica, 52, 2, 2014. Crossref

  3. Bhang Suk, Kim Byung-Soo, Combined Therapies of Cell Transplantation and Molecular Delivery, in Stem Cells and Revascularization Therapies, 20114041, 2011. Crossref

  4. Gounis M.J., Lieber B.B., Webster K.A., Wakhloo A.K., A Novel Angiographic Methodology for the Quantification of Angiogenesis, IEEE Transactions on Biomedical Engineering, 55, 3, 2008. Crossref

  5. Byzova Tatiana V., Goldman Corey K., Jankau Jurek, Chen Juhua, Cabrera Gustavo, Achen Marc G., Stacker Steven A., Carnevale Kevin A., Siemionow Maria, Deitcher Steven R., DiCorleto Paul E., Adenovirus encoding vascular endothelial growth factor–D induces tissue-specific vascular patterns in vivo, Blood, 99, 12, 2002. Crossref

  6. Gounis M J, Spiga M-G, Graham R M, Wilson A, Haliko S, Lieber B B, Wakhloo A K, Webster K A, Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle, Gene Therapy, 12, 9, 2005. Crossref

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