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Critical Reviews™ in Eukaryotic Gene Expression
編集マネージャー: Ariana Spatola (open in a new tab)

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Nuclear Phospholipase C in Biological Control and Cancer

巻 21, 発行 3, 2011, pp. 291-301
DOI: 10.1615/CritRevEukarGeneExpr.v21.i3.50
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Giulia Ramazzotti
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy
Irene Faenza
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy
Matilde Y. Follo
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy
Roberta Fiume
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy
Manuela Piazzi
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy
Roberto Giardino
Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy
Milena Fini
Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy
Lucio Cocco
University of Bologna

要約

Inositol lipids are key regulators of several cellular functions. The identification of an independent nuclear polyphosphoinositides signaling machinery has led the way to find new roles for these molecules. PI-PLC-β1 is the most extensively studied PLC isoform in the nuclear compartment and a key player in the regulation of nuclear lipid signaling. Nuclear PI-PLC-β1 is involved in cell cycle progression and differentiation in response to growth factor stimulation. A growing body of evidence has demonstrated that nuclear phosphoinositides are also involved in cancer cell generation, proliferation, and resistance to apoptosis. Evidence on ex vivo human cancer cells from patients with myelodysplastic syndromes (MDS) confirmed these observations, suggesting the involvement of PI-PLC-β1 both in the pathogenesis of the disease and in the progression of MDS to acute myeloid leukemia. These studies have offered new targets for the development of novel therapeutic strategies as well as new prognostic tools.

キーワード: nucleus, inositides, phospholipase C, myelodysplastic syndromes
によって引用された

  1. Mongiorgi Sara, Finelli Carlo, Yang Yong Ryoul, Clissa Cristina, McCubrey James A., Billi Anna Maria, Manzoli Lucia, Suh Pann-Ghill, Cocco Lucio, Follo Matilde Y., Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes, Expert Opinion on Therapeutic Targets, 20, 6, 2016. Crossref

  2. Piazzi Manuela, Blalock William L., Bavelloni Alberto, Faenza Irene, D'Angelo Antonietta, Maraldi Nadir M., Cocco Lucio, Phosphoinositide-specific Phospholipase C β 1b (PI-PLCβ1b) Interactome: Affinity Purification-Mass Spectrometry Analysis of PI-PLCβ1b with Nuclear Protein, Molecular & Cellular Proteomics, 12, 8, 2013. Crossref

  3. Poli Alessandro, Ratti Stefano, Finelli Carlo, Mongiorgi Sara, Clissa Cristina, Lonetti Annalisa, Cappellini Alessandra, Catozzi Alessia, Barraco Marilena, Suh Pann‐Ghill, Manzoli Lucia, McCubrey James A., Cocco Lucio, Follo Matilde Y., Nuclear translocation of PKC‐ α is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs), The FASEB Journal, 32, 2, 2018. Crossref

  4. Follo Matilde Y., Pellagatti Andrea, Ratti Stefano, Ramazzotti Giulia, Faenza Irene, Fiume Roberta, Mongiorgi Sara, Suh Pann-Ghill, McCubrey James A., Manzoli Lucia, Boultwood Jacqueline, Cocco Lucio, Recent advances in MDS mutation landscape: Splicing and signalling, Advances in Biological Regulation, 75, 2020. Crossref

  5. Owusu Obeng Eric, Rusciano Isabella, Marvi Maria Vittoria, Fazio Antonietta, Ratti Stefano, Follo Matilde Yung, Xian Jie, Manzoli Lucia, Billi Anna Maria, Mongiorgi Sara, Ramazzotti Giulia, Cocco Lucio, Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes, International Journal of Molecular Sciences, 21, 7, 2020. Crossref

  6. Ratti Stefano, Mongiorgi Sara, Rusciano Isabella, Manzoli Lucia, Follo Matilde Y., Glycogen Synthase Kinase-3 and phospholipase C-beta signalling: Roles and possible interactions in myelodysplastic syndromes and acute myeloid leukemia, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1867, 4, 2020. Crossref

  7. Katan Matilda, Cockcroft Shamshad, Phospholipase C families: Common themes and versatility in physiology and pathology, Progress in Lipid Research, 80, 2020. Crossref

  8. Cocco Lucio, Follo Matilde Y., Manzoli Lucia, Suh Pann-Ghill, Phosphoinositide-specific phospholipase C in health and disease, Journal of Lipid Research, 56, 10, 2015. Crossref

  9. Rashidi Sajad, Fernández-Rubio Celia, Manzano-Román Raúl, Mansouri Reza, Shafiei Reza, Ali-Hassanzadeh Mohammad, Barazesh Afshin, Karimazar Mohammadreza, Hatam Gholamreza, Nguewa Paul, Potential therapeutic targets shared between leishmaniasis and cancer, Parasitology, 148, 6, 2021. Crossref

  10. Rennie Madison, Lin Guanyu, Scarlata Suzanne, Multiple functions of phospholipase Cβ1 at a glance, Journal of Cell Science, 135, 18, 2022. Crossref

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