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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v11.i1-3.110
16 pages

Chromatin Domains and Regulation of Gene Expression: Familiar and Enigmatic Clusters of Chicken Globin Genes

Sergey V. Razin
Laboratory of Structural and Functional Organization of hromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Str. 34/5, 117334 Moscow, Russia
Felix Recillas-Targa
Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Departamento de Genetica Molecular, Apartado Postal 70-242, Mexico D.F. 04510, Mexico

要約

Chicken domains of a- and b-globin genes constitute traditional models to study possible relationships between the structural and functional organization of the eukaryotic genome. Recent evidence indicates that these two genomic domains differ significantly in genomic organization as well as in their mode of packaging into chromatin. In this review, we present a comparative analysis of the chicken a- and b-globin gene clusters. The data are discussed in terms of the “domain hypothesis of the eukaryotic genome organization.” On the basis of the results of our analysis, we present arguments for the existence of three distinct mechanisms that corroborate in the activation/repression of genomic domains. These mechanisms are (1) the relocation of genomic domains into nuclear compartments, (2) the long-term modifications of the mode of chromatin packaging within domains, and (3) the domain activation by continuous action of multiple transcription factors and remodeling complexes.


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