年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Regulation and Activities of α-Fetoprotein
要約
α-Fetoprotein (AFP) is one of the major serum proteins in the early life of mammals. The function of this protein is not yet fully understood. AFP is an oncodevelopmental gene product which is expressed at high levels in the embryonic yolk sac and fetal liver. The synthesis of AFP decreases dramatically after birth. Only trace amounts of AFP are synthesized in the adult liver. However, expression of the AFP gene is reactivated in the adult during liver regeneration and hepatocarcinogenesis. AFP is an excellent model system for studying the temporal and tissue-specific regulation of oncodevelopmental gene expression. Experiments with transgenic mice and DNA transfection studies have revealed several transcriptional control regions and cis-acting elements in the AFP gene. A large number of trans-acting protein factors interacting with these cis-acting elements have also been identified. Recent studies demonstrated that expression of AFP is regulated by at least two major signal transduction pathways in response to extracellular stimuli. The interactions between steroid hormone receptors and transcriptional factors which respond to separate signal transduction pathways result in transcriptional regulation of AFP gene expression. Trans-acting protein factors or steroid receptors complexed with given response elements can display different activities in different cell types due to cross-talk among both local protein-protein interactions within the DNA-binding domain, and distal protein-protein interactions. However, the detailed mechanisms of AFP gene expression are still not completely understood.
-
Pin Richard H., Reinblatt Maura, Fong Yuman, Utilizing α-Fetoprotein Expression to Enhance Oncolytic Viral Therapy in Hepatocellular Carcinoma, Annals of Surgery, 240, 4, 2004. Crossref
-
Mizejewski Gerald J, Biological role of α-fetoprotein in cancer: prospects for anticancer therapy, Expert Review of Anticancer Therapy, 2, 6, 2002. Crossref
-
Schievenbusch Stephanie, Sauer Elisabeth, Curth Harald-Morten, Schulte Sigrid, Demir Münevver, Toex Ulrich, Goeser Tobias, Nierhoff Dirk, Neighbor of Punc E 11: Expression Pattern of the New Hepatic Stem/Progenitor Cell Marker During Murine Liver Development, Stem Cells and Development, 21, 14, 2012. Crossref
-
Morris Shelli M., Baek Ji Yeon, Koszarek Amanda, Kanngurn Samornmas, Knoblaugh Sue E., Grady William M., Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss, Hepatology, 55, 1, 2012. Crossref
-
Jiao Ruiqing, He Qing-Yu, Chen Hongmin, Hua Zichun, Jiao Qincai, Chiu Jen-fu, AUF1-like protein binds specifically to DAScis-acting element that regulates mouse α-fetoprotein gene expression, Journal of Cellular Biochemistry, 98, 5, 2006. Crossref
-
Siripongsakun Surachate, Wei Sindy H, Lin Stephanie, Chen Jeffrey, Raman Steven S, Sayre James, Tong Myron J, Lu David S, Evaluation of alpha-fetoprotein in detecting hepatocellular carcinoma recurrence after radiofrequency ablation, Journal of Gastroenterology and Hepatology, 29, 1, 2014. Crossref
-
Chen Hongmin, Dong Jing-Ming, Liu Yi, Chiu Jen-Fu, Identification of a Cis-acting element in the rat ?-fetoprotein gene and its specific binding proteins in F9 cells during retinoic acid-induced differentiation, Journal of Cellular Biochemistry, 72, 1, 1999. Crossref
-
Mizejewski Gerald J., Levels of Alpha-Fetoprotein During Pregnancy and Early Infancy in Normal and Disease States, Obstetrical & Gynecological Survey, 58, 12, 2003. Crossref
-
Choi V.W.Y., Yu K.N., Embryos of the zebrafish Danio rerio in studies of non-targeted effects of ionizing radiation, Cancer Letters, 356, 1, 2015. Crossref
-
Hamamura Keisuke, Shiratori Yasushi, Shiina Shuichiro, Imamura Masatoshi, Obi Shuntaro, Sato Shinpei, Yoshida Haruhiko, Omata Masao, Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-?-carboxy prothrombin and low serum ?-fetoprotein, Cancer, 88, 7, 2000. Crossref
-
Chou Wan-Chih, Liao Kuang-Wen, Lo Yu-Chih, Jiang Shu Yaun, Yeh Ming Yang, Roffler Steve R., Expression of chimeric monomer and dimer proteins on the plasma membrane of mammalian cells, Biotechnology and Bioengineering, 65, 2, 1999. Crossref
-
Cho Chang-Won, Kim Chan-Wha, Toxicoproteomics in the study of aromatic hydrocarbon toxicity, Biotechnology and Bioprocess Engineering, 11, 3, 2006. Crossref
-
Li Xiaxin, Alexander Sarah, Hereditary persistence of alpha-fetoprotein, Pediatric Blood & Cancer, 52, 3, 2009. Crossref
-
Bois-Joyeux Brigitte, Chauvet Caroline, Nacer-Chérif Habib, Bergeret Wilfrid, Mazure Nathalie, Giguère Vincent, Laudet Vincent, Danan Jean-Louis, Modulation of the Far-Upstream Enhancer of the Rat α-Fetoprotein Gene by Members of the RORα, Rev-erbα, and Rev-erbβ Groups of Monomeric Orphan Nuclear Receptors, DNA and Cell Biology, 19, 10, 2000. Crossref
-
Huang Mei-Chuan, Ke Li Kelly, Spear Brett T., The Mouse Alpha-Fetoprotein Promoter is Repressed in HepG2 Hepatoma Cells by Hepatocyte Nuclear Factor-3 (FOXA), DNA and Cell Biology, 21, 8, 2002. Crossref
-
Mizejewski Gerald J., Alpha-fetoprotein (AFP)-derived peptides as epitopes for hepatoma immunotherapy: a commentary, Cancer Immunology, Immunotherapy, 58, 2, 2009. Crossref
-
Feuerman Miriam H., Alpha Fetoprotein, in Wiley Encyclopedia of Molecular Medicine, 2002. Crossref
-
Ma Yanlei, Zhang Peng, Wang Feng, Yang Jianjun, Yang Zhe, Qin Huanlong, The relationship between early embryo development and tumourigenesis, Journal of Cellular and Molecular Medicine, 14, 12, 2010. Crossref
-
Park Bernard J., Brown Charles K., Hu Yun, Alexander H. Richard, Horti Jozsef, Raje Sangeeta, Figg William D., Bartlett David L., Augmentation of Melanoma-Specific Gene Expression Using a Tandem Melanocyte-Specific Enhancer Results in Increased Cytotoxicity of the Purine Nucleoside Phosphorylase Gene in Melanoma, Human Gene Therapy, 10, 6, 1999. Crossref
-
Ueno M., Nakashima J., Ohigashi T., Deguchi N., Ban S., Akita M., Murai M., Establishment of a testicular carcinoma cell line producing α-fetoprotein, BJU International, 88, 6, 2001. Crossref
-
Hong N.A., Flannery M., Hsieh S.N., Cado D., Pedersen R., Winoto A., Mice Lacking Dad1, the Defender against Apoptotic Death-1, Express Abnormal N-Linked Glycoproteins and Undergo Increased Embryonic Apoptosis, Developmental Biology, 220, 1, 2000. Crossref
-
Alj Youssef, Georgiakaki Maria, Savouret Jean-François, Mal FrÉdÉric, Attali Pierre, Pelletier Gilles, Fourré Catherine, Milgrom Edwin, Buffet Catherine, Guiochon-Mantel Anne, Perlemuter Gabriel, Hereditary persistence of α-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations 1 1The authors thank Dr. A. Chauchereau for the gift of A9TKCAT vector, Dr. O. Lahuna for helpful discussion, C. Aumas for excellent technical assistance, and S. Wenk for careful English proofreading of the text. We are grateful for the cooperation of the patients and their families., Gastroenterology, 126, 1, 2004. Crossref
-
Zhang Hai, Cao Dongmei, Zhou Luting, Zhang Ye, Guo Xiaoqin, Li Hui, Chen Yuxia, Spear Brett T., Wu Jia-Wei, Xie Zhifang, Zhang Weiping J., ZBTB20 is a sequence-specific transcriptional repressor of alpha-fetoprotein gene, Scientific Reports, 5, 1, 2015. Crossref
-
Gjerris A. C., Tabor A., Loft A., Christiansen M., Pinborg A., First trimester prenatal screening among women pregnant after IVF/ICSI, Human Reproduction Update, 18, 4, 2012. Crossref
-
Long Lingyun, Davidson Jeffrey N, Spear Brett T, Striking differences between the mouse and the human α-fetoprotein enhancers, Genomics, 83, 4, 2004. Crossref
-
Watt Alistair J., Jones Elizabeth A., Ure Jan M., Peddie Diana, Wilson David I., Forrester Lesley M., A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm, Mechanisms of Development, 100, 2, 2001. Crossref
-
Spear Brett T., Alpha-fetoprotein gene regulation: lessons from transgenic mice, Seminars in Cancer Biology, 9, 2, 1999. Crossref
-
Tkatchenko Andrei V, Le Cam Ginette, Léger Jean J, Dechesne Claude A, Large-scale analysis of differential gene expression in the hindlimb muscles and diaphragm of mdx mouse, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1500, 1, 2000. Crossref
-
Franceschini Roberto, Picciotto Antonio, Cataldi Angelo, Corsini Giovanni, Sinelli Nicoletta, Bruno Emanuela, Barreca Tommaso, Rolandi Ermanno, Effect of interferon therapy on serum alpha-fetoprotein levels in patients with chronic hepatitis C virus infection, Current Therapeutic Research, 59, 4, 1998. Crossref
-
Kaetzel David M, Transcription of the platelet-derived growth factor A-chain gene, Cytokine & Growth Factor Reviews, 14, 5, 2003. Crossref
-
Newby D., Dalgliesh G., Lyall F., Aitken D.A., Alphafetoprotein and alphafetoprotein receptor expression in the normal human placenta at term, Placenta, 26, 2-3, 2005. Crossref
-
Peyton David K., Huang Mei-Chuan, Giglia Meredith A., Hughes Nedda K., Spear Brett T., The Alpha-fetoprotein Promoter Is the Target of Afr1-Mediated Postnatal Repression, Genomics, 63, 2, 2000. Crossref
-
Pereda Jaime, Sulz Lorena, Monge Juan I., The role of the gastrointestinal epithelium as a possible pathway for the transfer of nutrients to the embryo's circulation, Microscopy Research and Technique, 78, 6, 2015. Crossref
-
Baxter Melissa A., Rowe Cliff, Alder Jane, Harrison Sean, Hanley Karen Piper, Park B. Kevin, Kitteringham Neil R., Goldring Chris E., Hanley Neil A., Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening, Stem Cell Research, 5, 1, 2010. Crossref
-
Bois-Joyeux B, Cailliau K, Danan J.-L, Regulation of alpha-fœtoprotein gene expression by fatty acids and fibrates, Prostaglandins, Leukotrienes and Essential Fatty Acids, 60, 5-6, 1999. Crossref
-
Jones Elizabeth A., Tosh David, Forrester Lesley M., Liver, in Handbook of Stem Cells, 2004. Crossref
-
Sarandakou Angeliki, Protonotariou Efthimia, Rizos Demetrios, Tumor Markers In Biological Fluids Associated With Pregnancy, Critical Reviews in Clinical Laboratory Sciences, 44, 2, 2007. Crossref
-
Fukasaw Hiroko, Iwamoto Hideki, Hirata Shuji, Shoda Tomoko, Yokota Sadaki, Nishi Shinzo, Hoshi Kazuhiko, Novel Human Alpha-Fetoprotein mRNA Isoform Lacking Exon 1 Identified in Ovarian Yolk Sac Tumor, Journal of the Society for Gynecologic Investigation, 12, 6, 2005. Crossref
-
Sharony Reuven, Zadik Idit, Parvari Ruti, Congenital deficiency of alpha feto-protein, European Journal of Human Genetics, 12, 10, 2004. Crossref
-
Mizejewski Gerald J., Biological Roles of Alpha-Fetoprotein During Pregnancy and Perinatal Development, Experimental Biology and Medicine, 229, 6, 2004. Crossref
-
Spivak Graciela, Itoh Toshiki, Matsunaga Tsukasa, Nikaido Osamu, Hanawalt Philip, Yamaizumi Masaru, Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers, DNA Repair, 1, 8, 2002. Crossref
-
Mizejewski Gerald J., Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants, Experimental Biology and Medicine, 226, 5, 2001. Crossref
-
Mizejewski Gerald J., Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome, Experimental Biology and Medicine, 232, 8, 2007. Crossref
-
Li Meng-Sen, The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line, World Journal of Gastroenterology, 8, 3, 2002. Crossref
-
Dokuzeylül Güngör Nur, Gürbüz Tuğba, Gökmen Karasu Ayşe Filiz, Erşahin Aynur, The alteration of first trimester screening markers in fresh and frozen-thawed blastocyst transfers, The European Research Journal, 2018. Crossref
-
Dokuzeylül Güngör Nur, Gürbüz Tuğba, Erşahin Aynur, The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results, Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2018. Crossref
-
Wilkinson Deepti S., Barton Michelle Craig, Tumor Suppressors p53 and TGFβ Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker, in Transforming Growth Factor-β in Cancer Therapy, Volume II, 2008. Crossref
-
Gerresheim Gesche, Bathke Jochen, Michel Audrey, Andreev Dmitri, Shalamova Lyudmila, Rossbach Oliver, Hu Pan, Glebe Dieter, Fricke Markus, Marz Manja, Goesmann Alexander, Kiniry Stephen, Baranov Pavel, Shatsky Ivan, Niepmann Michael, Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling, International Journal of Molecular Sciences, 20, 6, 2019. Crossref
-
Cassinat Bruno, Guardiola Philippe, Chevret Sylvie, Schlageter Marie-Hélène, Toubert Marie-Elisabeth, Rain Jean-Didier, Gluckman Eliane, Constitutive elevation of serum alpha-fetoprotein in Fanconi anemia, Blood, 96, 3, 2000. Crossref
-
Cassinat Bruno, Guardiola Philippe, Chevret Sylvie, Schlageter Marie-Hélène, Toubert Marie-Elisabeth, Rain Jean-Didier, Gluckman Eliane, Constitutive elevation of serum alpha-fetoprotein in Fanconi anemia, Blood, 96, 3, 2000. Crossref
-
Pin Richard H., Reinblatt Maura, Fong Yuman, Jarnagin William R., Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials, in Gene Therapy for Cancer, 2007. Crossref
-
Shen Suqin, Feng Huan, Liu Longjiang, Su Wei, Yu Long, Wu Jiaxue, TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma, BMB Reports, 53, 8, 2020. Crossref
-
Watson Carole S., Bialek Peter, Anzo Makoto, Khosravi Javad, Yee Siu-Pok, Han Victor K. M., Elevated Circulating Insulin-Like Growth Factor Binding Protein-1 Is Sufficient to Cause Fetal Growth Restriction, Endocrinology, 147, 3, 2006. Crossref
-
Reimold Andreas M., Etkin Amit, Clauss Isabelle, Perkins Andrew, Friend Daniel S., Zhang John, Horton Heidi F., Scott Andrew, Orkin Stuart H., Byrne Michael C., Grusby Michael J., Glimcher Laurie H., An essential role in liver development for transcription factor XBP-1, Genes & Development, 14, 2, 2000. Crossref
-
Schmitt Bianca M., Rudolph Konrad L.M., Karagianni Panagiota, Fonseca Nuno A., White Robert J., Talianidis Iannis, Odom Duncan T., Marioni John C., Kutter Claudia, High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface, Genome Research, 24, 11, 2014. Crossref
-
Kalinichenko Vladimir V., Major Michael L., Wang Xinhe, Petrovic Vladimir, Kuechle Joseph, Yoder Helena M., Dennewitz Margaret B., Shin Brian, Datta Abhishek, Raychaudhuri Pradip, Costa Robert H., Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor, Genes & Development, 18, 7, 2004. Crossref
-
Mor Amir, Gardezi Mursal, Jubanyik Karen, Simsek Burcin, Seifer David B., Patrizio Pasquale, Esencan Ecem, Imamoglu Gizem, Zhang Man, Nichols-Burns Stephanie M., Taylor Hugh S., Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads, Fertility and Sterility, 116, 2, 2021. Crossref
-
Chien Chih‐Cheng, Yen Betty Linju, Lee Fa‐Kung, Lai Tsung‐Hsuan, Chen Yao‐Chang, Chan Shu‐Hui, Huang Hsing‐I, In Vitro Differentiation of Human Placenta‐Derived Multipotent Cells into Hepatocyte‐Like Cells, STEM CELLS, 24, 7, 2006. Crossref
-
Kang Mee Jeong, Lee Do-Youn, Joo Won-A, Kim Chan-Wha, Plasma Protein Level Changes in Waste Incineration Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Journal of Proteome Research, 4, 4, 2005. Crossref
-
Baer R J, Chambers C D, Ryckman K K, Oltman S P, Norton M E, Jelliffe-Pawlowski L L, Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein, Journal of Perinatology, 37, 3, 2017. Crossref
-
Kajiyama Yasuo, Tian Jianmin, Locker Joseph, Regulation of α-Fetoprotein Expression by Nkx2.8, Molecular and Cellular Biology, 22, 17, 2002. Crossref
-
Kubota Hiroshi, Storms Robert W., Reid Lola M., Variant Forms of α-Fetoprotein Transcripts Expressed in Human Hematopoietic Progenitors, Journal of Biological Chemistry, 277, 31, 2002. Crossref
-
Nguyen Thi T., Cho Kyucheol, Stratton Sabrina A., Barton Michelle Craig, Transcription Factor Interactions and Chromatin Modifications Associated with p53-Mediated, Developmental Repression of the Alpha-Fetoprotein Gene, Molecular and Cellular Biology, 25, 6, 2005. Crossref
-
Wilkinson Deepti S., Ogden Stacey K., Stratton Sabrina A., Piechan Julie L., Nguyen Thi T., Smulian George A., Barton Michelle Craig, A Direct Intersection between p53 and Transforming Growth Factor β Pathways Targets Chromatin Modification and Transcription Repression of the α-Fetoprotein Gene, Molecular and Cellular Biology, 25, 3, 2005. Crossref
-
Xie Zhifang, Zhang Hai, Tsai Wenwei, Zhang Ye, Du Yu, Zhong Jigen, Szpirer Claude, Zhu Minghua, Cao Xuetao, Barton Michelle Craig, Grusby Michael J., Zhang Weiping J., Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver, Proceedings of the National Academy of Sciences, 105, 31, 2008. Crossref
-
Nakabayashi Hidekazu, Koyama Yoshikazu, Sakai Masaharu, Li Hong Mei, Wong Norman C.W., Nishi Shinzo, Glucocorticoid Stimulates Primate but Inhibits Rodent α-Fetoprotein Gene Promoter, Biochemical and Biophysical Research Communications, 287, 1, 2001. Crossref
-
Crowe Alison J., Sang Ling, Li Kelly Ke, Lee Kathleen C., Spear Brett T., Barton Michelle C., Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the α-Fetoprotein Gene, Journal of Biological Chemistry, 274, 35, 1999. Crossref
-
Harju Susanna, Navas Patrick A., Stamatoyannopoulos George, Peterson Kenneth R., Genome Architecture of the Human β-Globin Locus Affects Developmental Regulation of Gene Expression, Molecular and Cellular Biology, 25, 20, 2005. Crossref
-
Hanke Petra, Serwe Matthias, Dombrowski Frank, Sauerbruch Tilman, Caselmann Wolfgang H, DNA vaccination with AFP-encoding plasmid DNA prevents growth of subcutaneous AFP-expressing tumors and does not interfere with liver regeneration in mice, Cancer Gene Therapy, 9, 4, 2002. Crossref
-
Zaidi Sayyed K., Frietze Seth E., Gordon Jonathan A., Heath Jessica L., Messier Terri, Hong Deli, Boyd Joseph R., Kang Mingu, Imbalzano Anthony N., Lian Jane B., Stein Janet L., Stein Gary S., Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer, Molecular and Cellular Biology, 37, 23, 2017. Crossref
-
Gabant Philippe, Forrester Lesley, Nichols Jennifer, Van Reeth Thierry, De Mees Christelle, Pajack Bernard, Watt Alistair, Smitz Johan, Alexandre Henri, Szpirer Claude, Szpirer Josiane, Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility, Proceedings of the National Academy of Sciences, 99, 20, 2002. Crossref
-
Kataoka Hiromi, Miura Yutaka, Joh Takashi, Seno Kyoji, Tada Toyohiro, Tamaoki Taiki, Nakabayashi Hidekazu, Kawaguchi Makoto, Asai Kiyofumi, Kato Taiji, Itoh Makoto, Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1, Oncogene, 20, 7, 2001. Crossref
-
Tagaya Hikaru, Fukasawa Hiroko, Shoda Tomoko, Hoshi Kazuhiko, Hirata Shuji, Novel Alpha-Fetoprotein-V Messenger RNA Isoforms in Humans, Reproductive Sciences, 16, 8, 2009. Crossref
-
Cai Qiu-Chen, Li Da-Lun, Zhang Ying, Liu Yun-Yi, Fang Pei, Zheng Si-Qin, Zhang Yue-Yan, Yang Ya-Kun, Hou Chun, Gao Cheng-Wei, Zhu Qi-Shun, Cao Chuan-Hai, Expression level comparison of marker genes related to early embryonic development and tumor growth, Oncology Letters, 24, 6, 2022. Crossref