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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i2.20
pages 103-113

Insights on the Functional Role of Chromatin Remodelers in Osteogenic Cells

Dafna Benayahu
Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Israel
Nitsan Shacham
Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Israel
Irena Shur
Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Israel

要約

Control of eukaryotic gene expression requires interaction between sequence-specific transcription factors and their regulatory elements on the particular promoter. The dynamic alteration of chromatin structure regulates the accessibility of these elements in the genome and therefore contributes to the control of transcrip-tional activity. Here we discuss chromatin remodelling in the context of osteoblast lineage regulation. This review specifically highlights the role of the protein chromatin-related mesenchymal modulator (CReMM/CHD9), a recently identified chromatin remodeler, in osteogenic cell differentiation.


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