ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i4.30
pages 289-300

Gene Expression in Stem Cells

Yu Liang
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Iain Russell
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Criss Walworth
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Caifu Chen
Life Technologies
N/A

要約

Both embryonic and adult stem cells promise a precious cell source for the treatment of various degenerative diseases due to their capacity for self-renewal and ability to differentiate along multiple cell lineages. A lack of understanding surrounding the basic biology of stem cells, the stemness, continues to challenge successful clinical application of these cells. Gene expression analysis, both genome-wide and targeted at specific gene subsets, has played a key role in improving our understanding of the genetic attributes of stem cells through identification of molecular signatures that characterize normal stem cell function. Such approaches have facilitated the investigation of stemness in a subset of tumor cells, so-called cancer stem cells, and have started to unravel their roles in initiation and progression of tumors. This review summarizes recent advances of gene expression analysis in stem cell research and also discusses critical issues that remain to be elucidated in the search for cancer stem cells markers.


Articles with similar content:

Deciphering Tumor Growth by Clonal Analysis
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 5
Gregory Driessens
Oncogenic RAS: From Its Activation to Its Direct Targeting
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 3-4
Apostolos Zaravinos
Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression Profiling
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 2
David N. Boone, Adrian V. Lee
Tracking Down the Origin of Cancer: Metabolic Reprogramming as a Driver of Stemness and Tumorigenesis
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 5
Carlos Sebastian
YY1 Is an Inducer of Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Guangchao Sui, Dangdang Li, Wenmeng Wang