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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015012469
pages 47-57

The Role Of Semaphorin 3A In The Skeletal System

Peifu Tang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Pengbin Yin
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Houchen Lv
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Licheng Zhang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Lihai Zhang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China

要約

Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone metabolism and as a potential drug target for bone disease therapy. We summarize Sema3A functions in osteoblastogenesis and osteoclastogenesis, as well as in innervation, and we discuss its multifunctional role in various bone diseases such as osteoporosis and low back pain. Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.


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