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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Sclerosing Bone Disorders: Too Much of a Good Thing

巻 20, 発行 3, 2010, pp. 195-212
DOI: 10.1615/CritRevEukarGeneExpr.v20.i3.20
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要約

Osteoporosis is, because of its high prevalence and morbidity, a major health problem in our aging population. Epidemiological studies clearly indicated a heritability of up to 80% for relevant bone parameters with an additional role for environmental factors, such as food intake and physical exercise. A major contribution to our current understanding of bone homeostasis is obtained by studying monogenic diseases with an increased bone density, the sclerosing bone dysplasias. Gene identifications have revealed relevant pathways and mechanisms both in the bone-resorbing osteoclasts and bone-forming osteoblasts. Furthermore, natural variants within these genes turned out to have an influence on bone mineral density in the general population. Finally, interesting drug targets for the prevention and treatment of osteoporosis were revealed. Although many major breakthroughs have been realized, still a huge amount of significant information is hidden in these pathologies as the function of many of these genes and newly identified pathways is not, or only partially, clear.

によって引用された
  1. Perdu Bram, Van Hul Wim, Sclerosing Bone Disorders, in Genetics of Bone Biology and Skeletal Disease, 2013. Crossref

  2. Perdu Bram, Mortier Geert, Vanhoenacker Filip, Van Hul Wim, Sclerosing Bone Dysplasias, in Pediatric Bone, 2012. Crossref

  3. Borra V.M., Steenackers E., de Freitas F., Van Hul E., Glass I., Van Hul W., Localization of the gene for X-linked calvarial hyperostosis to chromosome Xq27.3–Xqter, Bone, 58, 2014. Crossref

  4. Sobacchi Cristina, Schulz Ansgar, Coxon Fraser P., Villa Anna, Helfrich Miep H., Osteopetrosis: genetics, treatment and new insights into osteoclast function, Nature Reviews Endocrinology, 9, 9, 2013. Crossref

  5. Waterval J.J., Borra V.M., Van Hul W., Stokroos R.J., Manni J.J., Sclerosing bone dysplasias with involvement of the craniofacial skeleton, Bone, 60, 2014. Crossref

  6. Borra V. M., Waterval J. J., Stokroos R. J., Manni J. J., Van Hul W., Localization of the Gene for Hyperostosis Cranialis Interna to Chromosome 8p21 with Analysis of Three Candidate Genes, Calcified Tissue International, 93, 1, 2013. Crossref

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  11. Boudin Eveline, Van Hul Wim, Sclerosing Bone Disorders, in Genetics of Bone Biology and Skeletal Disease, 2018. Crossref

  12. Okur Fatma Visal, Cevher İnci, Özdemir Cansu, Kocaefe Çetin, Çetinkaya Duygu Uçkan, Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods, Stem Cell Research & Therapy, 10, 1, 2019. Crossref

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