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Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v16.i1.50
pages 61-102

PET-Based Biological Imaging for Radiation Therapy Treatment Planning

Pat Zanzonico
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY

要約

Biologically conformal radiation therapy (BCRT), a convergence of intensity-modulated radiation therapy (IMRT) and positron emission tomography (PET)-based functional imaging, incorporates patient-specific, image-derived biological information. This approach may potentially lead to a paradigm shift in radiation therapy—spatially varying dose prescriptions, or dose sculpting, for individualized and dosimetrically optimized treatment. This article reviews the current status of the technical, biological, and clinical aspects of PET-guided radiation therapy. It remains unclear, however, whether PET is currently capable of delineating the true extent of viable tumor with sufficient accuracy and precision to reliably guide therapy on a routine basis.


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