ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 2.156 5年インパクトファクター: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i3.30
pages 251-278

Matrix Metalloproteinase Control of Capillary Morphogenesis

Cyrus M. Ghajar
Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA
Steven C. George
Department of Biomedical Engineering, Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, CA 92697, USA
Andrew Putnam
Univ. of California, Irvine

要約

Matrix metalloproteinases (MMPs) play crucial roles in a variety of normal (e.g., blood vessel formation, bone development) and pathophysiological (e.g., wound healing, cancer) processes. This is not only due to their ability to degrade the surrounding extracellular matrix (ECM), but also because MMPs function to reveal cryptic matrix binding sites, release matrix-bound growth factors inherent to these processes, and activate a variety of cell surface molecules. The process of blood vessel formation, in particular, is regulated by what is widely classified as the angiogenic switch: a mixture of both pro- and antiangiogenic factors that function to counteract each other unless the stimuli from one side exceeds the other to disrupt the quiescent state. Although it was initially thought that MMPs were strictly proangiogenic, new functions for this proteolytic family, such as mediating vascular regression and generating matrix fragments with antiangiogenic capacities, have been discovered in the last decade. These findings cast MMPs as multifaceted pro- and antiangiogenic effectors. The purpose of this review is to introduce the reader to the general structure and characterization of the MMP family and to discuss the temporal and spatial regulation of their gene expression and enzymatic activity in the following crucial steps associated with angiogenesis: degradation of the vascular basement membrane, proliferation and invasion of endothelial cells within the subjacent ECM, organization into immature tubules, maturation of these nascent vessels, and the pruning and regression of the vascular network.


Articles with similar content:

Developmental Regulation of Elastin Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Steven Perrin , Judith Ann Foster
Regulation and Regulatory Role of the Retinoids
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
Shehnaaz Manji, T. John Martin, Hong Zhou, Kong Wan Ng
Interactions of Migrating T Lymphocytes, Inflammatory Mediators, and the Extracellular Matrix
Critical Reviews™ in Immunology, Vol.15, 1995, issue 3-4
Rami Hershkoviz, Sylvia G. Kachalsky, Ofer Lider
Heparan Sulfate Control of Proliferation and Differentiation in the Stem Cell Niche
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 2
Victor Nurcombe, Simon M. Cool
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield