年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
MicroRNAs in Bladder Cancer: Expression Profiles, Biological Functions, Regulation, and Clinical Implications
要約
Bladder cancer (UBC) is a common cancer worldwide and has a high rate of recurrence and progression despite systemic therapy. The molecular mechanisms of UBC are not completely understood. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles in multiple steps during the progression of UBC. Here, we review the expression profiles of miRNAs and their biological functions, regulation, and clinical implications in UBC. Either down-regulation or up-regulation of miRNAs occurs in UBC through epigenetic changes or defects of the biogenesis apparatus. Deregulation of miRNAs is involved in cell-cycle arrest, apoptosis, proliferation, metastasis, drug resistance, and other functions in UBC. A number of miRNAs, including urine miRNAs, have been associated with tumor type, stage, or patient survival, and miRNAs might be developed as diagnostic or prognostic markers. Better understanding of the roles of miRNAs in UBC will shed light on the molecular mechanisms of UBC.
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Wang Chenghe, Chen Zhong, Ge Qiangqiang, Hu Junhui, Li Fan, Hu Jia, Xu Hua, Ye Zhangqun, Li Long-Cheng, Up-regulation of p21WAF1/CIP1by miRNAs and its implications in bladder cancer cells, FEBS Letters, 588, 24, 2014. Crossref
-
Lv Lei, Li Yang, Deng Hui, Zhang Cheng, Pu Youguang, Qian Liting, Xiao Jun, Zhao Weidong, Liu Qi, Zhang Daming, Wang Yingwei, Zhang Hongyu, He Yinghua, Zhu Jingde, MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene, Cancer Letters, 357, 1, 2015. Crossref
-
Armstrong David A., Green Benjamin B., Seigne John D., Schned Alan R., Marsit Carmen J., MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer, Molecular Cancer, 14, 1, 2015. Crossref
-
Li Zheng, Yu Xin, Shen Jianxiong, Chan Matthew T.V., Wu William Ka Kei, MicroRNA in intervertebral disc degeneration, Cell Proliferation, 48, 3, 2015. Crossref
-
Liang Zhen, Li Shiqi, Xu Xin, Xu Xianglai, Wang Xiao, Wu Jian, Zhu Yi, Hu Zhenghui, Lin Yiwei, Mao Yeqing, Chen Hong, Luo Jindan, Liu Ben, Zheng Xiangyi, Xie Liping, MicroRNA-576-3p Inhibits Proliferation in Bladder Cancer Cells by Targeting Cyclin D1, Molecules and Cells, 38, 2, 2015. Crossref
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Wei Yanping, He Rongquan, Wu Yuzhuang, Gan Binliang, Wu Peirong, Qiu Xiaohui, Lan Aihua, Chen Gang, Wang Qiuyan, Lin Xinggu, Chen Yingchun, Mo Zengnan, Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues, Tumor Biology, 37, 9, 2016. Crossref
-
Huang Jun, Wang Bin, Hui Ke, Zeng Jin, Fan Jinhai, Wang Xinyang, Hsieh Jer-Tsong, He Dalin, Wu Kaijie, miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion, Oncology Reports, 36, 3, 2016. Crossref
-
Igietseme Joseph U., Omosun Yusuf, Stuchlik Olga, Reed Matthew S., Partin James, He Qing, Joseph Kahaliah, Ellerson Debra, Bollweg Brigid, George Zenas, Eko Francis O., Bandea Claudiu, Liu Hsi, Yang Genyan, Shieh Wun-Ju, Pohl Jan, Karem Kevin, Black Carolyn M., Seshu J., Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis, PLOS ONE, 10, 12, 2015. Crossref
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Mafi Alireza, Aghadavod Esmat, Mirhosseini Naghmeh, Mobini Moein, Asemi Zatollah, The effects of expression of different microRNAs on insulin secretion and diabetic nephropathy progression, Journal of Cellular Physiology, 234, 1, 2019. Crossref
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Xiao Haiping, MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2, Cellular & Molecular Biology Letters, 24, 1, 2019. Crossref
-
Ma Yingyu, Luo Wei, Bunch Brittany L., Pratt Rachel N., Trump Donald L., Johnson Candace S., 1,25D3 differentially suppresses bladder cancer cell migration and invasion through the induction of miR-101-3p, Oncotarget, 8, 36, 2017. Crossref
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Peng Yang, Dong Wen, Lin Tian-xin, Zhong Guang-zheng, Liao Bei, Wang Bo, Gu Peng, Huang Li, Xie Yun, Lu Fu-ding, Chen Xu, Xie Wei-bin, He Wang, Wu Shao-xu, Huang Jian, MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1, Oncotarget, 6, 18, 2015. Crossref
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Chen Jianying , Song Bo , Kong Guangqi , MicroRNA‑663b downregulation inhibits proliferation and induces apoptosis in bladder cancer cells by targeting TUSC2, Molecular Medicine Reports, 2019. Crossref
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Gao Ji , Li Hongyan , Liu Lei , Song Lide , Lv Yanting , Han Yuping , Identification and functional analysis of risk‑related microRNAs for the prognosis of patients with bladder urothelial carcinoma, Oncology Letters, 2017. Crossref
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Wang Rong, Wu Yunfeng, Huang Weihua, Chen Weijun, MicroRNA-940 Targets INPP4A or GSK3β and Activates the Wnt/β-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 26, 1, 2018. Crossref