ライブラリ登録: Guest
International Journal of Physiology and Pathophysiology

年間 4 号発行

ISSN 印刷: 2155-014X

ISSN オンライン: 2155-0158

SJR: 0.116

Effect of Germanium Citrate on Immunophysiological Activity of the Rats' Organism

巻 9, 発行 1, 2018, pp. 17-26
DOI: 10.1615/IntJPhysPathophys.v9.i1.30
Get accessGet access

要約

The effects of various doses of gemanium citrate on immunophysiological mechanisms of homeostatic reactions in rats of different age and physiological conditions were studied. It has been revealed that daily exposure of female rats and their offspring to germanium citrate, obtained by nanotechnology (groups II–IV) and chemical synthesis (groups V–VI), in doses of 10, 20, 200, and 2000 μg/kg results in immunophysiological changes in the organism of animals in all research groups. In the blood of female rats after 4 months of treating with germanium, and in the blood of their offspring (V and VI groups) on the 60–65th day of life, the content of immunoglobulins increases 1.73–2.45 times (females) and 1.05–1.1 times (males); the content of circulating immune complexes increased 1.12–3.10 and 1.27–2.02 times; the content of sialic acids increased 1.01–1.54 and 1.39–1.58 times; and the content of protein-bound hexoses increased 1.12–1.17 and 1.20–1.33 times, respectively. In all rats, the content of medium-weight molecules is reduced by 6–17%, the platelet count decreased in females and males by 22–39% and 6–23%, respectively, as well as phagocytic activity decreased by 5.3–10.2% and 4.4–5.7%, respectively, indicating the same direction of immunobiological action of citrate germanium in adults and young rats of different sexes. The concentration of ceruloplasmin and the number of leukocytes decreased in females of groups III–VI and grew in males of groups II–VI. Based on the analysis of the immune system indicators and the content of glycoproteins in the blood, we have assessed the immunophysiological features of the effects of low and high doses of germanium citrate depending on the duration of its intake and systemic communication of mother and fetus. The obtained results testify to gender and agedependent features of hepato-immunological communication of these animals under prolonged treating with germanium citrate. Biological effect of the latter is more pronounced in rats receiving it in doses of 20 and 200 μg/kg.

によって引用された
  1. Fedoruk R. S. , Tesarivska U. I. , Kovalchuk I. I. , Tsap M. M. , Kaplunenko V. H. , Koleschuk O. I. , Khrabko M. I. , Biological effects of iodine, selenium, sulfur citrates in broiler chickens , Regulatory Mechanisms in Biosystems, 12, 3, 2021. Crossref

761 記事の閲覧数 10 記事のダウンロード 記事の統計
761 記事の閲覧数 10 記事のダウンロード 1 Crossref 引用数 Google
Scholar
引用数

類似内容の記事:

Effect of Chronic Postnatal Stress on Pro-and Antioxidant System and Changes in Autonomic Balance of Cardiac Rhythm in Rats International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Iryna R. Mits, Olha V. Denefil
The Features of Sexual Behavior of Female Rats with Hyperandrogenia in Pubertal and Postpubertal Periods International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 1
Nadiya D. Nosenko, Anna A. Lymareva
Quantitative and Qualitative Composition of the Peripheral Blood of Fish in the Gradient of Long-Term Radiation Exposure Hydrobiological Journal, Vol.60, 2024, issue 1
O. Ye. Kaglyan, D. I. Gudkov, N. A. Pomortseva, N. K. Rodionova
The Assessment of Gadolinium Orthovanadate Nanoparticles Value for Neonatally-Induced Reproductive Disease in Male Rats International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 4
Vladimir K. Klochkov, Yury I. Karachentsev, Natalia P. Smolenko, Elina E. Chistyakova, Inna O. Belkina, Nina A. Karpenko, Yury V. Malukin
Cardiohemodynamics Parametrs and Proteasome Activity in the Aorta and Heart Tissues of Spontaneously Hypertensive Rat at Quercetin Application International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 2
Mariya O. Kuzmenko, Lesya V. Tumanovska, Viktor E. Dosenko, Oleksiy O. Moibenko, Sergii V. Goncharov, Georgiy Portnichenko, Denis O. Pashevin

最新号

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain