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International Journal of Physiology and Pathophysiology

年間 4 号発行

ISSN 印刷: 2155-014X

ISSN オンライン: 2155-0158

SJR: 0.116

Effect of ATP-Sensitive Potassium Channel Activation by Flocalin on the Functioning of the Cardiovascular System

巻 4, 発行 4, 2013, pp. 307-314
DOI: 10.1615/IntJPhysPathophys.v4.i4.40
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要約

At in vivo experiments on anesthetized dogs, the effect of Flocalin, fluorine-containing opener of ATP-sensitive potassium (KATP) channels, introduced intravenously in doses ranging from 0.01 to 1.5 mg / kg on cardio-hemodynamics was studied. Flocalin has been shown to reduce the systemic blood pressure, perfusion pressure in the coronary vessels and the total peripheral vascular resistance in a dose-dependent manner, with maximum effects of 56.8 ± 2.7, 22.4 ± 4.7 and 47.2% ± 6.5%, respectively. It causes the development of cardiodepresor responses, which is manifested as the reduction of the left ventricular pressure, the rate of the speed of growth (dP / dtmax) and decrease (dP / dtmin) of pressure in it, with the greatest effects of 37.1 ± 5.1, 51.2 ± 9.4 and 55.6% ± 6.9%, respectively when using Flocalin at a dose of 1.5 mg / kg. It also reduces the cardiac output and the heart rate, with maximum effects of 23.1 ± 12.7 and 19.2% ± 1.7%, respectively, at a dose of 1.0 mg / kg. It should be noted that the heart rate and the total peripheral resistance, were reduced significantly only by high doses of Flocalin (1 and 1.5 mg / kg). Thus, it has been shown that Flocalin-induced activation of KATP channels causes a decrease in the vascular tone and the myocardium contractile activity in a dose-dependent manner.

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