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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i4.40
pages 307-314

Effect of ATP-Sensitive Potassium Channel Activation by Flocalin on the Functioning of the Cardiovascular System

Ruslan B. Strutynskyi
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Roman A. Rovenets
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Nataliya A. Strutynska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Oleksander P. Neshcheret
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olexiy O. Moibenko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

要約

At in vivo experiments on anesthetized dogs, the effect of Flocalin, fluorine-containing opener of ATP-sensitive potassium (KATP) channels, introduced intravenously in doses ranging from 0.01 to 1.5 mg / kg on cardio-hemodynamics was studied. Flocalin has been shown to reduce the systemic blood pressure, perfusion pressure in the coronary vessels and the total peripheral vascular resistance in a dose-dependent manner, with maximum effects of 56.8 ± 2.7, 22.4 ± 4.7 and 47.2% ± 6.5%, respectively. It causes the development of cardiodepresor responses, which is manifested as the reduction of the left ventricular pressure, the rate of the speed of growth (dP / dtmax) and decrease (dP / dtmin) of pressure in it, with the greatest effects of 37.1 ± 5.1, 51.2 ± 9.4 and 55.6% ± 6.9%, respectively when using Flocalin at a dose of 1.5 mg / kg. It also reduces the cardiac output and the heart rate, with maximum effects of 23.1 ± 12.7 and 19.2% ± 1.7%, respectively, at a dose of 1.0 mg / kg. It should be noted that the heart rate and the total peripheral resistance, were reduced significantly only by high doses of Flocalin (1 and 1.5 mg / kg). Thus, it has been shown that Flocalin-induced activation of KATP channels causes a decrease in the vascular tone and the myocardium contractile activity in a dose-dependent manner.