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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i4.50
pages 315-324

Disorders of Oxygen-Dependent Processes in Periodontal Tissues under Prolonged Immobilization Stress and the Ways of Their Pharmacological Correction

Anna V. Opanasenko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Larisa. V. Bratus
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Bronislav L. Gavenauskas
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olga A. Gonchar
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Irina N. Mankovskaya
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Valentina I. Nosar
O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv
Stella B. Frantsuzova
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

要約

The effects of prolonged immobilization (6 h strict horizontal position of rats in the tight containers daily for 2 weeks) on oxygen tension in the gingival tissue, oxygen consumption by the mandible alveolar bone, pro-/antioxidant balance and energetic metabolism of soft periodontal tissues were investigated. It has been shown that prolonged immobilization stress results in a marked decrease in the gingival tissue PO2 (by 36%), oxygen consumption rate in the bone tissue (by 46%), and a reduction in the gingival mitochondrial respiration rate, compared to the control values. The latter is more significantly manifested in case of oxidation of α-ketoglutarate, NAD-dependent substrate of the respiratory chain, compared to succinate, FAD-dependent one. The prolonged stress results in intensification of peroxide processes and a depletion of antioxidant protection of the soft periodontal tissues. It has been found that pharmacological drugs Thiotriazolin and Actovegin possess modifying protective effect on stress-induced disorders of oxygen homeostasis in the soft and hard periodontal tissues under prolonged immobilization stress.