年間 4 号発行
ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158
Cardiohemodynamics and Efficiency of the Frank-Starling Mechanism in Spontaneously Hypertensive Rats
要約
In a study on rats with genetically determined hypertension and control Wistar rats, we investigated the features of cardio-hemodynamics and an efficiency of Frank-Starling mechanism. Rats were anesthetized with urethane (1.25 g / kg, i.p). Changes in the left ventricular pressure and volume with visualization of the pressure-volume curves during the cardiac cycle were recorded using ultra small catheter 2F ("Millar Instruments", USA). Cardio-hemodynamic parameters of the left ventricle were analyzed using PVAN 3.6 program. It has been found that spontaneously hypertensive rats, at rest, demonstrate less efficient heart function at higher energy and oxygen consumption. After volume loading, an increase in the performance of the heart pump and contractile functions is less pronounced, compared to those in rats of the control group. Frank-Starling mechanism has been shown to be inhibited, when arterial stiffness increases. Thus, less efficient heart performance in rats with genetically determined hypertension to loading may be associated with reduced functional reserves of the heart and increased arterial stiffness.