ライブラリ登録: Guest
International Journal of Physiology and Pathophysiology

年間 4 号発行

ISSN 印刷: 2155-014X

ISSN オンライン: 2155-0158

SJR: 0.116

Mechanisms of Phase Changes in Energy Metabolism at Adaptation to Immobilization Stress: Role of Corticosterone

巻 6, 発行 4, 2015, pp. 313-322
DOI: 10.1615/IntJPhysPathophys.v6.i4.50
Get accessGet access

要約

When stress affects the organs and tissues, barrier function of the lungs is disordered. It leads to a syndrome of "stress-induced lung" and a decrease of oxygen delivery to the tissues, as well as to tissue hypoxia. The aim of the study was to determine the dynamics of oxygen consumption, blood glucose, body temperature, activities of oxidant and antioxidant systems, as well as mitochondrial respiration under the influence of chronic stress (immobilization for 6 hours daily for 3 weeks on Wistar rats). Four phases in energy metabolism change have been identified in the dynamics of chronic stress. In the first phase, hypometabolic, instability of oxidative metabolism and decrease in oxidation of NAD-dependent substrates were observed, but significant elevation in FAD-dependent substrate oxidation and low mitochondrial respiratory uncoupling (MRU) were found. An increase in activity of mitochindrial manganese superoxide dismutase (MnSOD) occurs on the background of low glutathione peroxidase activity and misbalance of the antioxidant system. After seven immobilizations, shift in energy metabolism (second phase) occurs, and then the third phase (hypermetabolic) starts. The latter is characterized by a gradual increase in oxidative metabolism, the restoration of oxidation of NAD-dependent substrates, MRU, as well as optimizing balance of oxidant and antioxidant systems. The fourth phase occurs after 15 immobilization sessions, and it is characterized by the development of adaptive reactions, including increased tolerance of energy metabolism to the impact of immobilization. The results obtained correlate to changes in the dynamics of blood corticosterone. Thus, the phase character of the energy metabolism has been found during the chronic stress.

367 記事の閲覧数 4 記事のダウンロード 記事の統計
367 記事の閲覧数 4 記事のダウンロード Google
Scholar
引用数

類似内容の記事:

Energy and Antioxidant Status of Rat Liver Mitochondria during Hypoxia- Reoxygenation of Different Duration International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 4
Larisa. V. Bratus, N. N. Steshenko, Valentina I. Nosar, I. N. Tymchenko, Olga A. Gonchar, Iryna N. Mankovska
Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 2
Alla M. Sydorenko, Alla G. Portnychenko, Volodymyr I. Portnichenko, Valentina I. Nosar, Irina N. Mankovskaya
The Features of Sexual Behavior of Female Rats with Hyperandrogenia in Pubertal and Postpubertal Periods International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 1
Nadiya D. Nosenko, Anna A. Lymareva
Hormonal Changes in Female Rats Exposed to Chronic Stress and Androgen Excess at Pubescence International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 1
Olga V. Sachynska, I. Yu. Ganzhiy, Nadiya D. Nosenko, Larisa V. Tarasenko, Pyotr V Sinitsyn, Alexander G. Reznikov
Involvement of Some Subtypes of 5-HT2-Receptors in Affective Behavior in Female Rats International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 1
Yu. O. Fedotova, N. E. Ordyan, Valery I. Sobolev, Galina O. Frolova

最新号

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain