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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i3.90
pages 261-281

Endoplasmic Reticulum Stress and Angiogenesis in Cancer

Dmytro O. Minchenko
Department of Molecular Biology, Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, Kyiv, Ukraine; Bogomolets National Medical University, Kyiv, Ukraine
Kateryna I. Kubaichuk
Department of Molecular Biology, Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olena V. Hubenia
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine; Shupik National Medical Academy of Post-Graduate Education, Kyiv, Ukraine
Iryna V. Kryvdiuk
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Anastasia P. Kharkova
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Ruslana M. Herasymenko
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Roman V. Sulik
Shupik National Medical Academy of Post-Graduate Education, Kyiv, Ukraine
Leonid L. Karbovskyi
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Oleksandr H. Minchenko
Department of Molecular Biology, Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, Kyiv, Ukraine

要約

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis, which provides stringent quality control of proteins to ensure that only correctly folded proteins transit to the Golgi apparatus, while unfolded or misfolded ones are retained and ultimately degraded. The endoplasmic reticulum stress represents the cell response to unfolded or misfolded proteins in the ER to cope with its accumulation, therefore it is necessary to maintain the functional integrity of the endoplasmic reticulum. The endoplasmic reticulum stress is a fundamental phenomenon which provides a secure protection of the cells from different factors. This kind of stress provides a wide spectrum of physiological roles in diverse developmental and metabolic processes, especially for professional secretory cells with high-level secretory protein synthesis, such as pancreatic β-cells, hepatocytes and osteoblasts, and it is required throughout the entire life. The endoplasmic reticulum stress, like hypoxia, is the obligate component of malignant tumor growth, both of them are interconnected in angiogenesis activation via growth and metabolism control. The endoplasmic reticulum stress is mediated by three sensor and signaling pathways (PERK, ATF6, and ERN1) and contributes to the development of malignant tumors. It should be noted that blockade of one of them, ERN1, a major signaling parhway, leads to a decrease in tumor growth intensity through suppression of angiogenesis and proliferation. Moreover, blockade only endoribonuclease activity of ERN1, which controls transcription factor XBP1 splicing and c-JUN N-terminal kinases activation, has more robust effect on glioma cells proliferation. The data concerning the interaction of signaling enzyme ERN1 and pro- and anti-angiogenic gene expressions are analyzed.


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