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Ethics in Biology, Engineering and Medicine: An International Journal
SJR: 0.123

ISSN 印刷: 2151-805X
ISSN オンライン: 2151-8068

Ethics in Biology, Engineering and Medicine: An International Journal

DOI: 10.1615/EthicsBiologyEngMed.2020033718
pages 37-49

Ethics of Using Animal Models as Predictors of Human Response in Tissue Engineering

Jessica M. Falcon
Tissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122
James P. Karchner
Tissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122
Elizabeth A. Henning
McKay Orthopedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104
Robert L. Mauck
McKay Orthopedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104
Nancy Pleshko
Tissue Imaging and Spectroscopy Lab, Department of Bioengineering, Temple University, Philadelphia, PA 19122

要約

Use of outcomes from animal research for prediction of human response in tissue engineering studies has many ethical considerations. This article aims to contribute to the ethical discussion by delineating the framework of animal research and the ethical considerations at play, in particular with respect to cartilage tissue engineering. The history of animal research regulation and the current status of animal research in orthopedic tissue engineering is discussed. Questions addressed include how the proper animal models are chosen, how regulatory bodies ensure animal wellness and safety, and how guidelines are implemented and maintained throughout the life cycle of a project. Finally, we provide examples of both in vitro and in vivo cartilage tissue engineering research where animal models were employed as a predictive model of human response.

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