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Ethics in Biology, Engineering and Medicine: An International Journal

ISSN 印刷: 2151-805X

ISSN オンライン: 2151-8068

SJR: 0.123

The Ethics of Gene Editing Technologies in Human Stem Cells

巻 5, 発行 4, 2014, pp. 323-338
DOI: 10.1615/EthicsBiologyEngMed.2015013732
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要約

The advent of clustered, regularly interspaced, short palindromic repeat (CRISPR) technology and the maturation human stem technology now provide a powerful toolkit for personalized regenerative medicine. The correction of genetic aberrations within patient stem cells through the use CRISPR allows researchers to easily and precisely change the DNA sequence at specific areas on the chromosome in stem cells and in vivo models with minimal off target effects. CRISPR could make gene correction therapies more widely available and may provide treatments for a range of simple and complex genetic diseases.
On the surface, the advent and use of gene correction/editing technologies is a powerful tool to reduce human suffering through the eradicating complex disease with a genetic etiology. In this paper, we critically analyze "the gene correction as therapy for complex diseases" hypothesis. We approach this analysis from an ethical perspective by developing an anticipatory ethical analysis of potential issues related to the intersection between gene editing technology and human stem cell research. Particular attention is paid to the concept that gene editing/correction strategies may reduce human genetic diversity in the process of alleviating human suffering.

によって引用された
  1. Kashi A., Saha S., Ethical Issues in Biomaterials Research, in Materials for Bone Disorders, 2017. Crossref

  2. Nestor Michael W., Wilson Richard L., Beyond Mendelian Genetics: Anticipatory Biomedical Ethics and Policy Implications for the Use of CRISPR Together with Gene Drive in Humans, Journal of Bioethical Inquiry, 17, 1, 2020. Crossref

  3. Nestor Michael W., Wilson Richard L., The Use and Access to CRISPR in Historically Socioeconomically Disadvantaged and Marginalized Communities, in Anticipatory Ethics and The Use of CRISPR in Humans, 2022. Crossref

  4. Nestor Michael W., Wilson Richard L., Introduction to Anticipatory Ethics, in Anticipatory Ethics and The Use of CRISPR in Humans, 2022. Crossref

  5. Liu Jiqing, Zhang Gui, Lv Xiaojing, Li Jiayu, Discovering the Landscape and Evolution of Responsible Research and Innovation (RRI): Science Mapping Based on Bibliometric Analysis, Sustainability, 14, 14, 2022. Crossref

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