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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effect of Grifola frondosa (Dicks.:Fr.) S.F.Gray (Maitake Mushroom) Aqueous Extract on Nitric Oxide Production Induced by BCG and Cytokines in Rat Hepatocytes

巻 8, 発行 1, 2006, pp. 49-55
DOI: 10.1615/IntJMedMushr.v8.i1.60
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要約

ABSTRACT: To examine the effect of the Grifola frondosa (maitake mushroom) aqueous extract (MAE) on nitric oxide (NO) production induced by BCG pretreatment in vivo plus cytokines mixture (CM) stimulating conditions in vitro in primary cultured rat hepatocytes. NO accumulations were induced by BCG pretreatment (125 mg kg−1, 2 weeks, i.v.) in vivo or by BCG plus cytokine mixture (CM, including TNF-α, IL-1β, IFN-γ, and LPS) stimulating a in culture medium in vitro. NO production in the cultured supernatant was determined by the Griess reaction. Application of MAE alone did not show marked effects on NO production (P > 0.05) in cultured hepatocytes, even though it was administered after 48 hr and at higher concentrations (800 mg L−1). Under the presence of BCG or/and CM conditions, NO production was significantly increased by MAE at 400 mg L−1 ∼ 800 mg L−1 concentrations (P < 0.05 and P < 0.01, respectively) as the time-dependent manner in culture supernatant. But in similar BCG plus CM stimulating conditions, administration of MAE inhibited NO production at a range of lower concentrations (from 50 mg L−1 to 200 mg L−1, P < 0.05). On the other hand, both aminoguanidine and actinomycin D (ActD), which are inhibitors of selective iNOS enzyme activity and iNOS mRNA transcription, significantly inhibited BCG plus CM-induced NO production in rat hepatocytes (P < 0.05). The results of the present study not only further support the possibility that MAE might be an immunomodulating agent, but also confirm the immune effective mechanism of MAE by regulating NO production both in vivo and in vitro.

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