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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025324
pages 61-70

Antioxidant Activity of Water Extract from Fermented Mycelia of Cordyceps sobolifera (Ascomycetes) in Caenorhabditis elegans

Qun-Ying Lin
Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, Jiangsu, China
Liang-Kun Long
Department of Pharmaceutical Engineering, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu, China
Zi-Heng Zhuang
School of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, China
Liang-Liang Wu
Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, Jiangsu, China
Shu-Ling Wu
Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, Jiangsu, China
Wei-Ming Zhang
Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, Jiangsu, China

要約

This research aimed to evaluate the potential of Cordyceps sobolifera in mycelial biomass production via liquid culture and to assay the safety and determine the antioxidative and antiaging activities of Caenorhabditis elegans. A C. sobolifera isolate was cultured using the one-factor-at-a-time method to illustrate its carbon and nitrogen requirements. To assess safety, we determined the lethality, locomotion behavior, and reproduction of C. elegans cultured on a mycelial water extract (MWE) containing nematode growth medium (NGM). To investigate antiaging activity, C. elegans treated with MWE was incubated on NGM plates. The lethality was recorded throughout the whole life cycle. To identify antioxidant activity, C. elegans treated with MWE was exposed to paraquat, causing superoxide conditions. The results showed that C. sobolifera was favored by glucose and peptone as carbon and nitrogen sources, respectively. MWE was considered to be safe, as no abnormal behaviors were observed in C. elegans. Compared with nematodes pretreated with no MWE but with water instead, MWE at 1.0 mg/mL significantly prolonged the mean lifespan of C. elegans by 24%. We observed an obvious dose-effect relation between concentration and mean lifespan. The effective antioxidant activity was recorded at the high concentration of MWE. These findings demonstrate the potential antiaging and antioxidant properties of C. sobolifera as functional food and dietary supplement.


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