年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Suppressing the Formation of Osteoclasts Using Bioactive Components of the Edible Mushroom Leccinum extremiorientale (L Vass.) Singer (Agaricomycetideae)
要約
Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.
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Wu Jing, Choi Jae-Hoon, Yoshida Miyuki, Hirai Hirofumi, Harada Etsuko, Masuda Kikuko, Koyama Tomoyuki, Yazawa Kazunaga, Noguchi Keiichi, Nagasawa Kazuo, Kawagishi Hirokazu, Osteoclast-forming suppressing compounds, gargalols A, B, and C, from the edible mushroom Grifola gargal, Tetrahedron, 67, 35, 2011. Crossref
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Ito Akinobu, Wu Jing, Ozawa Nobuhiko, Choi Jae-Hoon, Hirai Hirofumi, Kawagishi Hirokazu, Plant growth regulators from the edible mushroom Leccinum extremiorientale, Mycoscience, 58, 6, 2017. Crossref
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Xu Congcong, Li Jiao, Su Li, Tang Hua, Zhang Wen, Osteoclastogenesis Modulatory Steroids from the South China Sea Gorgonian Coral Iciligorgia sp. , Chemistry & Biodiversity, 17, 6, 2020. Crossref
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Wu Jing, Kawagishi Hirokazu, Plant growth regulators from mushrooms, The Journal of Antibiotics, 73, 10, 2020. Crossref