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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i4.60
pages 391-400

Antioxidant and Anti-inflammatory Properties of New Medicinal Fungus, Auriculoscypha anacardiicola D.A.Reid et Manim. (Agaricomycetideae), from India

Bijesh Puthusseri
Department of Botany, University of Calicut, India
Thozhuthumparambil P. Smina
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680 555, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Patinjareveettil Manimohan
Department of Botany, University of Calicut, India

要約

Antioxidant and anti-inflammatory activities of the aqueous-ethanolic extract of Auriculoscypha anacardiicola fruiting bodies were investigated. Antioxidant activity of the extract was evaluated using DPPH, superoxide anion, FRAP, nitric oxide scavenging and lipid peroxidation inhibition assays. The extract was found to be a potent free radical scavenger and antioxidant. The extract showed significant DPPH scavenging activity (IC50: 31.36±2 μg/mL), ferric reducing antioxidant power (IC50: 3.4±0.5 μg/mL) and lipid peroxidation inhibiting activity (IC50: 79.81±2.77 μg/mL). Anti-inflammatory activity of the extract was determined using carrageenan induced acute and formalin induced chronic inflammatory models in Swiss albino mice. The extract showed profound acute and chronic anti-inflammatory activity. The extract at 500 mg/kg body weight showed higher anti-inflammatory activity than the standard reference drug diclofenac, administered at 10 mg/kg body weight, for both acute and chronic inflammation in mice. This is the first report of the medicinal properties of A. anacardiicola.


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