要約

We examined the anti-tumor property of Ganoderma lucidum fruiting body powder on Sprague Dawley rats fed with different formula diets for a period of 6 months. The previous studies had proved that benzo(a) pyrene [B(a)p], a polycyclic aromatic hydrocarbon, might cause skin cancer in an animal model. The presences of egg yolk as highly cholesterol diet increased the stress on the respective groups of rats. In the present study, rats were divided into four groups with a sample size of 6 rats per group. They are the Control group, 1% cholesterol diet (Chol) group, 1% G. lucidum powder (GF) group, and cholesterol with G. lucidum powder (Chol+GF) group. For all the rats, a total of five areas, each with a surface area of about 1.5×1.5 cm², were shaved and topically applied with B(a)p. At regular intervals, blood samples were taken and analyzed. The results revealed that the Chol+GF group had body weight lower than the Chol group. The GF group had their serum total cholesterol, triglycerides and low density lipoprotein concentrations significantly lower but higher high density lipoprotein cholesterol than those in the Chol group. The malondialdehyde level in the Chol+GF group was significantly suppressed as compared to the Chol group. In the liver, there was no significant difference in Glutathione S−Transferase levels between the GF and Chol+GF groups. However, in the lung, the Glutathione S−Transferase level was 30% lower in the Chol+GF group than the GF group. Histology studies indicated increasing abnormal hair follicles in the skin tissue of Control positive and Chol groups, but still no visible neoplastic nodules were formed. The GF and Chol+GF groups showed normal hair growth with normal hair follicles. The commercial G. lucidum fruiting body powder is tested as a type of a potent cancer chemo preventive agent in SD rats’ skin.