ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i5.60
pages 425-431

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice

Shu-Ming Huang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Department of Nutrition, Nantou Hospital, Ministry of Health and Welfare, Nantou City, Taiwan, R.O.C.
Jen-Yin Chen
Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, R.O.C.
Chin-Chu Chen
Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan
Chih-Chung Su
Department of Oncology, Jan-Ai Hospital-DaLi, Taichung, Taiwan, R.O.C.
Miao-Lin Hu
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, R.O.C.

要約

We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days. Results reveal that 8-Gy radiation caused death in 100% of mice on day 13, and 6-Gy radiation caused death in 86.7% of mice (13/15) at the end of the experiment, whereas 4- and 5-Gy radiation did not result in any death. We then used 5-Gy γ-ray radiation to examine the protective effects of PLEs. Mice were orally administered a PLE (500, 1000, and 1500 mg/kg) daily for 2 weeks before radiation and for 6 weeks after radiation. γ-Ray radiation significantly decreased body weight starting from week 2 after radiation. Supplementation with a median and high dose of PLE significantly restored body weights starting at weeks 5 and 3, respectively. The radiation-protective agent WR2721 (200 mg/kg intraperitoneally) restored body weights starting at week 4. White blood cells, platelets, red blood cells, and hemoglobin were significantly decreased by radiation, and PLEs (primarily at high doses) and WR2721 significantly prevented hematologic abnormality. These results suggest that PLE has potential as a radioprotective agent.


Articles with similar content:

Modulatory Effect of Crude Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes), on Hematological and Antioxidant Indices in Plasmodium berghei−infected Mice
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 5
Olarewaju M. Oluba, Kayode E. Adebisi, E. Chukwu Onyeneke, Adewale A. Odutuga, George O. Eidangbe
Inhibition of Hep G2 Hepatic Cancer Cell Growth and CCl4 Induced Liver Cytotoxicity in Swiss Albino Mice by Mahua Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Sudipta Ray, Murmu Nabendu, Jyotirmay Adhikari, Samir Banerjee, Sumanto Adhikari, Sayantan Bhattacharyya
Protective Effect of Diltiazem (a Calcium Channel Blocker) against Cadmium-Induced Toxicity in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Pradeep Kumar Goyal, Vandana Nunia
Radioprotection by Oral Administration of Aegle marmelos (L.) Correa In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Ponemone Venkatesh, Ganesh Chandra Jagetia
Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
Veronica T. Dias, Valdemiro A. da Silva Junior, M.E. Burger, Geisa S. Dolci, Katiane Roversi, Camila S. Pase, Luiz André de Lima, Caren T. D. Antoniazzi, Leandro M. de Carvalho, Fernanda Lima, Hecson J. Segat, Patricia Reckziegel, Raquel C. S. Barcelos, N. Boufleur, Dalila Benvegnu, Fabiola Trevizol