年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice
要約
We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days. Results reveal that 8-Gy radiation caused death in 100% of mice on day 13, and 6-Gy radiation caused death in 86.7% of mice (13/15) at the end of the experiment, whereas 4- and 5-Gy radiation did not result in any death. We then used 5-Gy γ-ray radiation to examine the protective effects of PLEs. Mice were orally administered a PLE (500, 1000, and 1500 mg/kg) daily for 2 weeks before radiation and for 6 weeks after radiation. γ-Ray radiation significantly decreased body weight starting from week 2 after radiation. Supplementation with a median and high dose of PLE significantly restored body weights starting at weeks 5 and 3, respectively. The radiation-protective agent WR2721 (200 mg/kg intraperitoneally) restored body weights starting at week 4. White blood cells, platelets, red blood cells, and hemoglobin were significantly decreased by radiation, and PLEs (primarily at high doses) and WR2721 significantly prevented hematologic abnormality. These results suggest that PLE has potential as a radioprotective agent.
-
Kumar Amith, Kumarchandra Reshma, Rai Rajalakshmi, Kumblekar Vasavi, Radiation mitigating activities of Psidium guajava L. against whole-body X-ray-induced damages in albino Wistar rat model, 3 Biotech, 10, 12, 2020. Crossref
-
Liang Chih-Hung, Wu Chiu-Yeh, Ho Wai-Jane, Liang Zeng-Chin, Influences of carbon and nitrogen source addition, water content, and initial pH of grain medium on hispidin production of Phellinus linteus by solid-state fermentation, Journal of Bioscience and Bioengineering, 130, 6, 2020. Crossref
-
Xia Yongjun, Yang Caiyun, Liu Xiaofeng, Wang Guangqiang, Xiong Zhiqiang, Song Xin, Yang Yijin, Zhang Hui, Ai Lianzhong, Enhancement of triterpene production via in situ extractive fermentation of Sanghuangporus vaninii YC‐1 , Biotechnology and Applied Biochemistry, 2022. Crossref