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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immunostimulating and Antitumor Effects by Inonotus obliquus (Ach.:Pers.) Pilat

巻 7, 発行 3, 2005, 406 pages
DOI: 10.1615/IntJMedMushrooms.v7.i3.500
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要約

Although it has been reported that Chaga Inonotus obliquus (Hymenochaetaceae) shows immuno-enhancement activity and antioxidant activity, protective effects against radiation have not been investigated. In addition, although a few studies on antitumor effects in vitro have been reported, it is unknown whether these effects also occur in vivo. Many studies on the protective effects of Propolis against radiation and its antitumor activity have been undertaken using water and ethanol extracts, but studies on the whole lysate, in which the original Propolis is completely dissolved, have not been done. It is unknown what mechanisms are involved in the protective effect against radiation and the antitumor activity in these substances.
Therefore, in this study, we investigated the protective effects against radiation and in vivo antitumor effects of Inonotus obliquus. In addition, we investigated the quite novel protective effect against radiation and antitumor activity of the whole Propolis lysate. Blood cells are one of the indices for evaluating protective effects against radiation. Hemopoietic tissues and peripheral lymphocytes are highly sensitive to radiation, and a decrease of immunity caused by a decrease in white blood cells and myelocytes is remarkable after exposure to radiation. Therefore, in this study, we focused on the antioxidant activity and immuno-enhancement activity of Inonotus obliquus and Propolis and examined the in vivo effect of radiation on the number of peripheral blood cells. Furthermore, measurement of T lymphocyte subsets, SOD-like activity, antioxidant activity, radical scavenging activity based on chemiluminescent methods, and absolute amounts of free radicals based on ESR were carried out, and radical scavenging activity, which is a mechanism of protection from radiation, was examined. In addition, we examined antioxidant activity and immuno-enhancement activity, both of which are closely related to tumor suppression, and further investigated effects on suppressive effects on tumor growth and antitumor effects of tumor necrosis factor (TNF).
The current major therapies for tumors are surgery, radiation, and chemotherapy. Immunotherapy is hoped to become a fourth therapeutic modality in the future. All of the three main therapies impose a burden on the body and weaken immunofunction. However, we hope that a combination of immunotherapy, using natural materials such as Inonotus obliquus and Propolis with immuno-enhancement action, may increase the percentage of patients who recover.

によって引用された
  1. DOĞAN Elif, KARADEMİR Güler, GEDİKLİ Semin, OKUR Sıtkıcan, Effects of oral and topical Momordica charantia-Propolis premix on wound healing, Harran Üniversitesi Veteriner Fakültesi Dergisi, 9, 1, 2020. Crossref

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