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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Medicinal Mushrooms: A New Source for Breast Cancer Therapeutics

巻 7, 発行 3, 2005, pp. 445-446
DOI: 10.1615/IntJMedMushrooms.v7.i3.840
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要約

It is known that advanced breast cancers do not respond well to chemotherapy, and their gene expression arouses uncontrolled growth. Although ER-positive breast cancers respond to hormonal therapy, the treatment of ER-negative cancers is more complicated. Despite the positive results of most of the chemotherapeutic regimes, cellular adaptations have enabled tumor cells to evade many of the chemotherapeutic drugs. One of these cellular chemoresistance factors is the transcription factor nuclear factor-kappa B (NF-κB). NF-κB can be such a target in breast cancer treatment, and its removal by an inhibitor can reverse the specific antiapoptosis of cancer cells. Therefore, NF-κB was selected as the main target in the present study.
Recently, the application of low-molecularweight compounds with fungal origin as natural therapeutics in cancer treatment has been gaining more attention. There are studies demonstrating that these biologically active fungal substances could be used as a novel pharmaceutical source in breast cancer therapy (Petrova et al., 2005). For instance, the caffeic acid phenethyl ester (CAPE), which specifically inhibits DNA binding of NF--κB and showed some promising results in human breast cancer MCF-7 cells, is found to be produced by Agaricus bisporus (J.E. Lange) Imbach, Lentinus edodes (Berk.) Singer, and Phellinus linteus (Berk. Et M.A. Curtis) Teng (Mattila et al., 2001; Nakamura et al., 2003). Low-molecular-weight compounds isolated from fruit bodies and spore extracts of Ganoderma lucidum (W.Curt.: Fr.) P. Karst. Also exhibited breast cancer and, more specifically, NF--κB inhibitory activity (Sliva et al., 2002; Sliva, 2003; Jiang et al., 2004).
Following these perspectives, we started a screening program of 75 strains of 67 species, kept in the Culture Collection of the Institute of Evolution, University of Haifa (HAI), belonging to different taxonomical and ecological groups. Mycelia were grown in submerged conditions for biomass production. Three organic solvents with different polarities (ethyl alcohol, ethyl acetate, and diethyl ether) were used for dry biomass extraction in order to isolate fungal secondary metabolites. Moreover, the culture broth, left after the mycelia filtration, was also extracted with ethyl acetate in order to receive bioactive compounds produced in the media during fungal growth.

によって引用された
  1. Petrova Roumyana D., Mahajna Jamal, Reznick Abraham Z., Wasser Solomon P., Denchev Cvetomir M., Nevo Eviatar, Fungal substances as modulators of NF-κB activation pathway, Molecular Biology Reports, 34, 3, 2007. Crossref

  2. Sun Jian-guo, Li Hua, Li Xia, Zeng Xueli, Wu Ping, Fung Kwok-Pui, Liu Fei-yan, Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo, Apoptosis, 19, 5, 2014. Crossref

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