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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

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Development and Optimization of the Triterpenoid and Sterol Production Process with Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum Strain G0017 (Agaricomycetes), in Liquid Submerged Fermentation at Large Scale

巻 23, 発行 3, 2021, pp. 43-53
DOI: 10.1615/IntJMedMushrooms.2021037830
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要約

Ganoderma lucidum mycelia are rich in active substances such as triterpenoids and sterols. However, reports on the development of effective submerged fermentation processes are lacking and the resulting total triterpene and sterol yield is still quite low. In this study, a new G. lucidum strain G0017 mycelium isolated by screening was studied in a 3-L fermenter to investigate the effect of aeration rate in liquid submerged fermentation production of triterpenoids and sterols. By fitting the specific mycelial growth rate and the specific production rate of the triterpenoid and sterol model, an effective multistage aeration rate control process for triterpenoid and sterol fermentation production was developed. This process was validated and proven in 3-L and 50-L fermenters. The resulting yields of triterpenoids and sterols were 3.34 and 3.46 g/L, respectively, which were 69.54% and 75.63% higher than the fixed aeration rate of 1.50 volume of air per volume of liquid per minute. This optimized fermentation production process conceivably could be applied to larger-scale industrial production and perhaps also to improve liquid submerged fermentation processes with relevant edible and medicinal mushrooms.

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によって引用された
  1. You Hao, Sun Bin, Li Na, Xu Jun-Wei, Efficient expression of heterologous genes by the introduction of the endogenous glyceraldehyde-3-phosphate dehydrogenase gene intron 1 in Ganoderma lucidum, Microbial Cell Factories, 20, 1, 2021. Crossref

  2. Yan Meng-Qiu, Su Xiao-Wei, Liu Yan-Fang, Tang Chuan-Hong, Tang Qing-Jiu, Zhou Shuai, Tan Yi, Liu Li-Ping, Zhang Jing-Song, Feng Jie, Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T’s Biosynthesis, Journal of Fungi, 8, 6, 2022. Crossref

  3. Zhang Ruyi, Han Yahong, McClements David Julian, Xu Duoxia, Chen Shuai, Production, Characterization, Delivery, and Cholesterol-Lowering Mechanism of Phytosterols: A Review, Journal of Agricultural and Food Chemistry, 70, 8, 2022. Crossref

  4. Meng Xianyao, Yang Yunli, Wu Yuehang, Zhang Ying, Zhang Hongyan, Zhou Weiqiang, Guo Miaomiao, Li Li, Inflammatory factor expression in HaCaT cells and melanin synthesis in melanocytes: Effects of Ganoderma lucidum fermentation broth containing Chinese medicine, International Journal of Food Properties, 25, 1, 2022. Crossref

  5. WANG Qingfu, HUANG Qinghua, ZHANG Liulian, WANG Lining, HU Biao, XU Riyi, LIANG Lei, PING Zhaohua, Evaluation of a sugarcane juice beverage fermented by Ganoderma lucidum: nutritional and antioxidant activity, Food Science and Technology, 42, 2022. Crossref

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2224 記事の閲覧数 46 記事のダウンロード 5 Crossref 引用数 Google
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