ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019031652
pages 875-894

Review of Advances in Bioactive Low-Molecular-Weight Compounds, Extracts, and Biology of Phellinus sensu lato Mushrooms (Agaricomycetes) from 2011 to 2017

Yating Dong
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Haile Ma
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Cunshan Zhou
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Golly K. Moses
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China; Faculty of Applied Sciences and Technology, Sunyani Technical University, Sunyani, Ghana
Xiaofei Ye
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China; Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville 37996, USA
Henan Zhang
National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, P.R. China
Ling Sun
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Mohammed A.Y. Abdualrahman
Department of Food Technology, Nyala Technical College, Southern Darfur State, Nyala, Sudan

要約

Various diseases such as cancer, hyperglycemia, and obesity negatively influence people's health and daily life. Mushroom species are miniature pharmaceutical factories producing hundreds of novel constituents with a long history of use in Oriental medicine. As a new therapy, they have attracted much attention owing to their potent therapeutic activity. Phellinus sensu lato (s.l.) is a well-known medicinal mushroom genus that has long been used in preventing ailments, including gastroenteric dysfunction, diarrhea, hemorrhage, and cancers, in Oriental countries, particularly in China, Japan, and Korea. Isolated compounds or complex extracts from Phellinus demonstrate specific bioactivity. Low-molecular-weight components, especially terpenoids, polyphenols, and other secondary metabolites, still exhibit biological activity. This review highlights the bioactive compounds from Phellinus s. l. mushrooms as being potent and having unlimited applications, especially the bioactive low-molecular-weight compounds, such as terpenoids, polyphenols, and their derivatives; also, pharmacological properties of the extracts and fractions from the fruiting bodies and the mycelia of Phellinus s. l., and the mechanism of the pharmacological activity have been discussed. This review summarized the two parts as mentioned above over a period of 7 years from 2011 to 2017.

参考

  1. Dai YC. Phellinus sensu lato (Aphyllophorales, Hymenochaetaceae) in East Asia. Acta Bot Fennica. 1999;(166):1-115.

  2. Zhu T, Kim SH, Chen CY. A medicinal mushroom: Phellinus linteus. Curr Med Chem. 2008;15(13):1330-35.

  3. Li YG, Ji DF, Zhong S, Zhu JX, Chen S, Hu GY. Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma. Int J Biol Macromol. 2011;48(3):511-17.

  4. Kozarskia M, Klausa A, Niksic M, Jakovljevi D, Helsper JPFG, Van Griensven LJLD. Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus. Food Chem. 2011;129(4):1667-75.

  5. Lim JH, Lee YM, Park SR, Kim dH, Lim BO. Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. Anticancer Res. 2014;34(8):4087-93.

  6. Hsieh PW, Wu JB, Wu YC. Chemistry and biology of Phellinus linteus. Ebiomedicine. 2013;3(3):106-13.

  7. Chen H, Tian T, Miao H, Zhao YY. Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review. Fitoterapia. 2016;113, 6-26.

  8. Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Omura S, Yoshikawa T, Kobayashi Y. y-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination. J Antibiot. 2017;70(5):695.

  9. Song AR, Sun XL, Kong C, Zhao C, Qin D, Huang F, Yang S. Discovery of a new sesquiterpenoid from Phellinus ignarius with antiviral activity against influenza virus. Arch Virol. 2014;159(4):753.

  10. Jang HJ, Yang KS. Inhibition of nitric oxide production in RAW 264.7 macrophages by diterpenoids from Phellinus pini. Arch Pharm Res. 2011;34(6):913-17.

  11. Huang SC, Hwang TL, Chan YY, Chen CH, Wu TS. Three novel sesquiterpenes from the mycelium of Phellinus linteus. Tetrahedron Lett. 2013;54(26):3332-35.

  12. Wang JZ, Hu F, Luo YC, Luo HJ, Huang NY, Cheng F, Deng ZS, Deng WQ, Zou K. Estrogenic and anti-estrogenic activities of hispolon from Phellinus lonicerinus (Bond.) Bond. et Sing. Fitoterapia. 2014;95:93-101.

  13. Hsiao PC, Hsieh YH, Chow JM, Yang SF, Hsiao M, Hua KT, Lin CH, Chen HY, Chien MH. Hispolon induces apoptosis through JNK1/2-Mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo. J Agr Food Chem. 2013;61(42):10063-73.

  14. Huang GJ, Deng JS, Huang SS, Hu ML. Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. J Agr Food Chem. 2011;59(13):7104-13.

  15. Chen YS, Lee SM, Lin CC, Liu CY. Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9. Int J Mol Sci. 2014;15(1):1201-15.

  16. Hsieh MJ, Chien SY, Chou YE, Chen CJ, Chen J, Chen MK. Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway. Phytomedicine. 2014;21(12):1746-52.

  17. Kim HJ, Choi BY, Kim HJ, Kim IY, Lee BE, Sohn M, Park HJ, Suh SW. A Water-ethanol extract from the willow bracket mushroom, Phellinus igniarius (higher Basidiomycetes), reduces transient cerebral ischemia-induced neuronal death. Int J Med Mushrooms. 2015;17(9): 879-89.

  18. Donatini B. Phellinus linteus: un mycelium prometteur en cancerologie ou contre les desordres immunitaires. Phytotherapie. 2011;9(4):221-24.

  19. Kim DE, Kim B, Shin HS, Kwon HJ, Park ES. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3beta and ERK1/2 signaling pathway. Exp Cell Res. 2014; 327(2):264-75.

  20. Park JM, Lee JS, Song JE, Sim YC, Ha SJ, Hong KE. Cytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes. Molecules. 2015;20:5456-67.

  21. Huang GJ, Hsieh WT, Chang HY. Alpha-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii. J Agr Food Chem. 2011;59(10):5702.

  22. Shao HJ, Jeong JB, Kim K, Lee S. Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-kB activation. J Sci Food Agr. 2015;95(12):2482-86.

  23. Lin CJ, Lien HM, Chang HY, Huang CL, Liu JJ, Chang YC, Chen CC, Lai CH. Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents. J Biosci Bioengin. 2014;118(1):88-93.

  24. Yin RH, Zhao ZZ, Chen HP, Yin X, Ji X, Dong ZJ, Li ZH, Feng T, Liu JK. Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius, and their vascular-relaxing activities. Phytochem Lett. 2014;10:300-03.

  25. Yin RH, Zhao ZZ, Ji X, Dong ZJ, Li ZH, Feng T, Liu JK. Steroids and sesquiterpenes from cultures of the fungus Phellinus igniarius. Nat Prod Bioprospect. 2015;5(1):17-22.

  26. Zheng WF, Zhao YX, Zheng X, Liu YB, Pan SY, Dai YC, Liu FM. Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus. Appl Microbiol Biotechnol. 2011;89(1):157- 67.

  27. Chen W, Feng L, Huang Z, Su H. Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation. Chem Biol Interact. 2012;199(3):137-42.

  28. Chen W, Shen Y, Su HM, Zheng XD. Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells. Chem Biol Interact. 2014;219:83-89.

  29. Lee JH, Lee JS, Kim YR, Jung WC, Lee KE, Lee SY, Hong EK. Hispidin isolated from Phellinus linteus protects against hydrogen peroxide-induced oxidative stress in pancreatic MIN6N beta-cells. J Med Food. 2011;14(11):1431-38.

  30. El Hassane A, Shah SA, Hassan NB, El Moussaoui N, Ahmad R, Zulkefeli M, Weber JF. Antioxidant activity of hispidin oligomers from medicinal fungi: a DFT study. Molecules. 2014;19(3):3489.

  31. Wu CS, Lin ZM, Wang LN, Guo DX, Wang SQ, Liu YQ, Yuan HQ, Lou HX. Phenolic compounds with NF-KB inhibitory effects from the fungus Phellinus baumii. Bioorg Med Chem Le. 2011;21(11):3261-67.

  32. Chao W, Deng JS, Huang SS, Li PY, Liang YC, Huang GJ. 3,4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways. Int Immunopharmacol. 2017;50:77-86.

  33. Yeom JH, Lee IK, Ki DW, Lee MS, Seok SJ, Yun BS. Neuraminidase inhibitors from the culture broth of Phellinus linteus. Mycobiology. 2012;40(2):142-44.

  34. Chen YC, Chang HY, Deng JS, Chen JJ, Huang SS, Lin IH, Kuo WL, Chao W, Huang GJ. Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells. Am J Chinese Med. 2013;41(06): 1439-57.

  35. Wang J, Chen B, Hu F, Zou X, Yu H, Wang J, Zhang H, He H, Huang W. Effect of hispolon from Phellinus lonicerinus (Agaricomycetes) on estrogen receptors, aromatase, and cyclooxygenase II in MCF-7 breast cancer cells. Int J Med Mushrooms. 2017;19(3):233-42.

  36. Cho JY, Kwon YJ, Sohn MJ, Seok SJ, Kim WG. ChemInform abstract: Phellinstatin (I), a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus. Bioorg Med Chem Lett. 2011;21(6):1716-18.

  37. Zhang HN, Shao Q, Wang WH, Zhang JS, Zhang Z, Liu YF, Yang Y. Characterization of compounds with tumor-cell proliferation inhibition activity from mushroom (Phellinus baumii) mycelia produced by solid-state fermentation. Molecules. 2017;22(5):698-709.

  38. Chang ZQ, Gebru E, Lee SP, Rhee MH, Kim HC, Park SC. In vitro antioxidant and anti-inflammatory activities of protocat-echualdehyde isolated from Phellinus gilvus. J Nutr Sci Vitaminol. 2011;57:118-22.

  39. Li L, Wu G, Choi BY, Jang BG, Kim JH, Sung GH, Cho JY, Suh SW, Park HJ. A mushroom extract Piwep from Phellinus igniarius ameliorates experimental autoimmune encephalomyelitis by inhibiting immune cell infiltration in the spinal cord. Biomed Res Int. 2014, 218274-doi: 10.1155/2014/218274.

  40. Ji SH. Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis. BMC Compl Altern Med. 2012;12(1):159-170.

  41. Choi DJ, Cho S, Seo JY, Lee HB, Yong IP. Neuroprotective effects of the Phellinus linteus, ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells. Nutr Res. 2016;36(1):31-43.

  42. Kim JH, Kim YC, Park B. Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors. Oncol Rep. 2016;35(2):1020-26.

  43. Im KH, Nguyen TK, Kim JK, Choi JH, Lee TS. Evaluation of anticholinesterase and inflammation inhibitory activity of medicinal mushroom Phellinus pini (Basidiomycetes) fruiting bodies. Int J Med Mushrooms. 2016;18(11):1011.

  44. Yang NC, Wu CC, Liu RH, Chai YC, Tseng CY. Comparing the functional components, SOD-like activities, antimutagenicity, and nutrient compositions of Phellinus igniarius and Phellinus linteus mushrooms. J Food Drug Anal. 2016;24(2):343- 49.

  45. Hong SB, Rhee MH, Yun BS, Lim YH, Song HG, Shin KS. Synergistic anti-bacterial effects of Phellinus baumii ethyl acetate extracts and P-Lactam antimicrobial agents against methicillin-resistant staphylococcus aureus. Ann Lab Med. 2016;36(2):111-16.

  46. Wang WH, Wu FH, Yang Y, Wu N, Zhang JS, Feng N, Tang CH. Hypoglycemic effect of ethanol and ethyl acetate extract of Phellinus baumii, fruiting body in streptozotocin-induced diabetic mice. Evid-Based Compl Alt. 2015;2015:1-7.

  47. Hokmollahi F, Rafati H, Riahi H, Hakimi M. Collection and identification of a medicinal mushroom, Phellinus Conchatus in Iran and investigation of the antibacterial activity of total methanol extract and fractional extracts. J Shahid Sadoughi Univ Med Sci. 2011;18(6):521-30.

  48. Sonawane H. Antimicrobial activity of some species of Phellinus and ganoderma sample from western ghats of India. Int J Pharm Sci Rev Res. 2012;3(6):1-5.

  49. Ayala-Zavala JF, Silva-Espinoza BA, Cruz-Valenzuela MR, Villegas-Ochoa MA, Esqueda M, Gonzalez-Aguilar GA, Calderon-Lopez Y. Antioxidant and antifungal potential of methanol extracts of Phellinus spp. from Sonora, Mexico. Rev Iberoam Micol. 2012;29(3):132-38.

  50. Shang XD, Tan Q, Liu R, Yu KY, Li PZ, Zhao GP. In vitro anti-helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion's Mane mushroom, hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2013;15(2):165-74.

  51. Natakankitkul S, Suabjakyong P, Toida T, Higashi K, Sato H, Ueno K, Chan F. Biological activities of natural Phellinus spp. mushroom in human cancer cells. TJPS. 2012;36:66-69.

  52. Park HJ. CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest. Molecules. 2014;19(9):14383-95.

  53. Hu W, Liu S, Zhang Y, Xun D, Xu C. Mycelial fermentation characteristics and antiproliferative activity of Phellinus vaninii Ljup. Pharmacogn Mag. 2014;10(40):430.

  54. Lee W, Chiang T. The ethanolic extract of Phellinus linteus, inhibits breast cancer cell growth through autophagy-related cell death. Eur J Cancer. 2014;50: S46-S46.

  55. Yang Y, Hu J, Liu Y, Feng N, Chen H, Tang Q, Ye L, Zhang J. Antioxidant and cytotoxic activities of ethanolic extracts and isolated fractions of species of the genus Phellinus Quel. (Aphyllophoromycetideae). Int J Med Mushrooms. 2011;13(2): 145-52.

  56. Jeon T, Hwang S, Jung YH, Hyo-Seon Y, Sung NY, Lee J, Park DK. Inhibitory effect of oral administration of Sangwhang mushroom (Phellinus linteus) grown on germinated brown rice on experimental lung metastasis and tumor growth in mice. Food Sci Biotechnol. 2011;20(1):209-14.

  57. Reza MA, Jo WS, Park SC. Comparative antitumor activity of jelly ear culinary-medicinal mushroom, Auricularia auricula-judae (Bull.) J. Schrot. (higher Basidiomycetes) extracts against tumor cells in vitro. Int J Med Mushrooms. 2012;14(4):403-09.

  58. Park HS. Physiological activities of extracts from Fomitella fraxinea on brown rice added rice bran, pine needle and tumeric powder. Korean J Mycol. 2011;39(2):111-116.

  59. Laovachirasuwan P, Judprakob C, Phadungkit M. Natural antioxidant activities of Phellinus mushroom extracts. Ann Nutr Metab. 2012;61(4):330-30.

  60. Seephonkai P, Samchai S, Thongsom A, Sunaart S, Kiemsanmuang B, Chakuton K. DPPH radical scavenging activity and total phenolics of Phellinus mushroom extracts collected from northeast of Thailand. China J Nat Med. 2011;9(6):441-45.

  61. Kovacs B, Zomborszki ZP, Orban-Gyapai O, Csupor-Loffler B, Liktor-Busa E, Lazar A, Papp V, Urban E, Hohmann J, Vanyolos A. Investigation of antimicrobial, antioxidant, and xanthine oxidase-inhibitory activities of Phellinus (Agarico-mycetes) mushroom species native to central Europe. Int J Med Mushrooms. 2017;19(5):387-94.

  62. Kim SH, Lim JH, Moon C, Park SH, Kim SH, Shin DH, Park SC, Kim JC. Anti-inflammatory and antioxidant effects of aqueous extract from Phellinus gilvus in rats. J Health Sci. 2011;57(2):171-76.

  63. Yayeh T, Oh WJ, Park SC, Kim TH, Cho JY, Park HJ, Lee IK, Kim SK, Hong SB, Yun BS, Rhee MH. Phellinus baumii ethyl acetate extract inhibits lipopolysaccharide-induced iNOS, COX-2, and proinflammatory cytokine expression in RAW264.7 cells. J Nat Med. 2012;66(1):49.

  64. Song M, Park HJ. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages. J Ethnopharmacol. 2014;154(2):311-18.

  65. Lee SW, Song JG, Hwang BS, Kim DW, Lee YJ, Woo EE, Kim JY, Lee IK, Yun BS. Lipoxygenase inhibitory activity of Korean indigenous mushroom extracts and isolation of an active compound from Phellinus baumii. Mycobiology. 2014;42(2):185-88.

  66. Yan GH, Yun HC. Phellinus linteus extract exerts anti-asthmatic effects by suppressing NF-KB and p38 MAPK activity in an OVA-induced mouse model of asthma. Immune Netw. 2014;14(2):107-15.

  67. Noh JR, Lee IK, Ly SY, Yang KJ, Gang GT, Kim YH, Hwang JH, Yun BS, Lee CH. A Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice. J Med Food. 2011;14(3):209-18.

  68. Seo JH, Sung YH, Kim KJ, Shin MS, Lee EK, Kim CJ. Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats. J Nutr Sci Vitaminol. 2011;57(1):95-103.

  69. Rony KA, Ajith TA, Nima N, Janardhanan KK. Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats. Environ Toxicol Phar. 2014;37(2):482-92.

  70. Ajith TA, Janardhanan KK. Antimutagenic effect of Phellinus rimosus (Berk) Pilat against chemical induced mutations of histidine dependent Salmonella typhimurium strains. Food Chem Toxicol. 2011;49(10):2676-80.

  71. Kamruzzaman SM, Endale M, Oh WJ, Park SC, Kim TH, Lee IK, Cho JY, Park HJ, Kim SK, Yun BS, Rhee MH. Antiplatelet activity of Phellinus baumii methanol extract is mediated by cyclic AMP elevation and inhibition of collagen-activated integrin-a(IIb) P3 and MAP kinase. Phytotherapy Res. 2011;25(11):1596-603.

  72. Lee D, Kim SC, Kim D, Kim JH, Park SP, Ryu YC, Kim M, Cho SK, Riu KZ, Lee DS. Screening of Phellinus linteus a medicinal mushroom for anti-viral activity. J Korean Soc Appl BI. 2011;54(3):475-78.

  73. Rony KA, Ajith TA, Mathew J, Janardhanan KK. The medicinal cracked-cap polypore mushroom Phellinus rimosus (higher Basidiomycetes) attenuates alloxan-induced hyperglycemia and oxidative stress in rats. Int J Med Mushrooms. 2013;15(3):287-300.

  74. Yayeh T, Lee WM, Ko D, Park SC, Cho JY, Park HJ, Lee IK, Kim SH, Hong SB, Kim Suk, Yun BS, Rhee MH. Phellinus baumii ethyl acetate extract alleviated collagen type II induced arthritis in DBA/1 mice. J Nat Med. 2013;67(4):807-13.

  75. Suzuki S, Kawamata T, Okada Y, Kobayashi T, Nakamura T, Hori T. Filtrate of Phellinus linteus broth culture reduces infarct size significantly in a rat model of permanent focal cerebral ischemia. Evid-Based Compl Alt. 2011;(1741-424X):326319.

  76. Kim YN, Kim MS, Chun SS, Choi JH. Effect of Phellinus linteus water extract on benign prostatic hyperplasia. Nutr Res Pract. 2013;7(3):172-77.

  77. Noh JR, Lee IK, Kim YH, Gang GT, Hwang JH, Ly SY, Yun BS, Lee CH. Antiatherogenic effect of antioxidant polyphenols from Phellinus baumii in apolipoprotein E-Deficient Mice. Ann Nutr Metab. 2011;59(2-4):145-53.

  78. Sainkhuu B, Park BS, Kim HW. Induction of flavin-containing monooxygenase in mice by oral administration of Phellinus baumii (Agaricomycetes) extract. Int J Med Mushrooms. 2016;18(9):793-806.

  79. Kim IH, Chung MY, Shin JY, Han D. Protective effects of black hoof medicinal mushroom from korea, Phellinus linteus (higher Basidiomycetes), on osteoporosis in vitro and in vivo. Int J Med Mushrooms. 2016;18(1):39-47.


Articles with similar content:

Biological Responses from Grifola frondosa (Dick.: Fr.) S. F. Gray−Maitake (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 4
Cun Zhuang, Takashi Mizuno
Medicinal Properties of Substances Occurring in Higher Basidiomycetes Mushrooms: Current Perspectives (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Biotechnological Potential of Mushrooms: Drugs and Dye Production
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 4
Girish Tidke, Mahendra K. Rai
Medically Significant White-Rot Basidiomycetes: Metabolic and Biochemical Characteristics
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Nina V. Belova, Natalia S. Yakovleva
Therapeutic Effects of Substances Occurring in Higher Basidiomycetes Mushrooms: A Modern Perspective
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis