年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer
要約
Preclinical studies have established that the polysaccharide fractions of Ganoderma lucidum have potent immunomodulating effects. A recent clinical study of healthy volunteers demonstrated that G. lucidum did not affect their immune functions. The present open-labeled study aimed to evaluate the effects of water-soluble G. lucidum polysaccharides (Ganopoly) in patients with advanced colorectal cancer. Forty-seven patients were enrolled and treated with Ganopoly at 5.4 g/day for 12 weeks. In 41 assessable cancer patients, treatment with Ganopoly tended to increase mitogenic reactivity to phytohemagglutinin; counts of CD3, CD4, CD8, and CD56; plasma concentrations of interleukin (IL)-2, IL-6, and interferon (IFN)-γ; and NK activity, but to decrease the plasma concentrations of IL-1 and tumor necrosis factor (TNF)-α. No statistical significance was observed when a comparison was conducted between baseline values and those after 12-week treatment with Ganopoly. The changes of IL-1 were correlated with those of IL-6, IFN-γ, CD3, CD4, CD8, and NK activity (p < 0.05), and IL-2 changes were correlated with those for IL-6, CD8, and NK activity. The results indicate that Ganopoly may have beneficial immunomodulating effects in patients with advanced colorectal cancer. Further studies are needed to explore the mode of action, efficacy, and safety of Ganopoly in cancer patients.
-
Zhu Xiao-Ling, Chen Alex-F., Lin Zhi-Bin, Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice, Journal of Ethnopharmacology, 111, 2, 2007. Crossref
-
Roupas Peter, Keogh Jennifer, Noakes Manny, Margetts Christine, Taylor Pennie, The role of edible mushrooms in health: Evaluation of the evidence, Journal of Functional Foods, 4, 4, 2012. Crossref
-
Jin Xingzhong, Ruiz Beguerie Julieta, Sze Daniel Man-yeun, Chan Godfrey CF, Jin Xingzhong, Ganoderma lucidum(Reishi mushroom) for cancer treatment, in Cochrane Database of Systematic Reviews, 2012. Crossref
-
Sze Daniel M.-Y., Liu Hao, Boost Maureen V., Wong Raimond, Sagar Stephen, PHYTOTHERAPEUTICS FOR CANCER THERAPY, in Phytotherapies, 2015. Crossref
-
Lemieszek Marta K., Nunes Fernando M., Rzeski Wojciech, Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon, Food & Function, 10, 9, 2019. Crossref
-
Jin Xingzhong, Ruiz Beguerie Julieta, Sze Daniel Man-yuen, Chan Godfrey CF, Ganoderma lucidum (Reishi mushroom) for cancer treatment, Cochrane Database of Systematic Reviews, 2019, 1, 2016. Crossref
-
Zeb Mehreen, Lee Chow H., Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America, Molecules, 26, 2, 2021. Crossref
-
Ahmad Rizwan, Riaz Muhammad, Khan Aslam, Aljamea Ahmed, Algheryafi Mohammad, Sewaket Deya, Alqathama Aljawharah, Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties , Phytotherapy Research, 35, 11, 2021. Crossref
-
Liu Hao, Wang Zi-Ying, Zhou Yu-Cong, Song Wei, Ali Usman, Sze Daniel M.-Y, Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review, Journal of Ethnopharmacology, 268, 2021. Crossref
-
Das Somenath, Prakash Bhanu, Edible mushrooms: Nutritional composition and medicinal benefits for improvement in quality life, in Research and Technological Advances in Food Science, 2022. Crossref